Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Control versus allergic rhinitis basal cells in response to Der p1

ABSTRACT: control versus allergic rhinitis basal cells in response to Der p1

PROVIDER: PRJNA1219057 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32221600.fastq.gz	Fastqsanger.gz
	SRR32221601.fastq.gz	Fastqsanger.gz
	SRR32221602.fastq.gz	Fastqsanger.gz
	SRR32221603.fastq.gz	Fastqsanger.gz
	SRR32221604.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

control versus allergic rhinitis basal cells in response to Der p1

Project description:Basal cells are the epithelial progenitor cells of the airways and play a critical role in tissue homeostasis and repair. In a healthy upper airway epithelium, the basal cells are usually shielded from environmental triggers as they are positioned in close contact with the basement membrane. In allergic rhinitis, it is known that the epithelial barrier is dysfunctional and it is believed that in this situation basal cells become more accessible to airborne particles, however, it is not known whether basal cells can sense these triggers directly. In addition, previous research has shown that control basal cells phenotypically and functionally differ from allergic rhinitis (AR) basal cells. In this study, we aimed to further compare phenotypical differences between sorted primary control and house dust mite (HDM)-allergic AR basal cells, before and after culture, using bulk RNA sequencing. Moreover, we wanted to evaluate the basal cell transcriptional response to HDM-derived Der p1 to study their potential as an environmental sensor.

2025-04-01 | GSE288682 | GEO

Global gene expression of nasal epithelial cells in patients with seasonal allergic rhinitis

Project description:Analysis of nasal epithelial cells from adult patients with seasonal allergic rhinitis and from non allergic controls. Results provide insight into the molecular mechanisms associated with inflammatory responses in nasal mucosa. Total RNA was obtained from nasal epithelial cells of 7 seasonal allergic rhinitis patients and 5 non-allergic control subjects

2015-01-16 | E-GEOD-43523 | biostudies-arrayexpress

Homo Sapiens Nasal Inferior Turbinates of house dust mite-induced allergic rhinitis and controls

Project description:To elucidate the epithelial cell diversity within the nasal inferior turbinates, a comprehensive investigation was conducted comparing control subjects to individuals with house dust mite-induced allergic rhinitis. This study aimed to delineate the differential expression profiles and phenotypic variations of epithelial cells in response to allergic rhinitis. This research elucidated distinct subpopulations and rare cell types of epithelial cells within the nasal turbinates, discerning alterations induced by allergic rhinitis. Furthermore, by interrogating transcriptomic signatures, the investigation provided novel insights into the cellular dynamics and immune responses underlying allergic rhinitis pathogenesis

2024-05-30 | GSE261706 | GEO

Global gene expression of nasal epithelial cells in patients with seasonal allergic rhinitis

2015-01-16 | GSE43523 | GEO

Allergen-challenged CD4+ cells from patients with seasonal allergic rhinitis

Project description:Seasonal allergic rhinitis (SAR) is a complex disease that is caused by many interacting genes and environmental factors. It is also an excellent model disease for clinical studies; it is common, it is seasonal, and since it takes place in the nasal cavity it can be studied in vivo non-invasively. Furthermore, the key disease cell, the Th2 cell is known. We study SAR using allergen-challenged CD4+ cells from allergic patients.

2009-10-16 | GSE18574 | GEO

Therapy of allergic rhinitis using ribavirin spray to clear nasal commensal viruses

Project description:To explore the impact of nasal commensal viruses on the onset and progression of allergic rhinitis, We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of CD45+ cells in the nasal mucosa of mice treated with Vehicle, Ribavirin, Vehicle-OVA, or Ribavirin-OVA.

2024-08-21 | GSE266238 | GEO

The differential expressed mRNAs in spleen B cells between control(normal)，PBS treated or SJMHE1(Schistosoma japonicum-derived peptide) treated OVA-induced allergic rhinitis mice.

Project description:In order to explore the molecular mechanism of SJMHE1 intervention in allergic rhinitis, an OVA-induced allergic rhinitis model was established and intervened by subcutaneous injection of PBS and SJMHE1. Then a global RNA sequencing of mouse spleen B cells from the control, PBS, and SJMHE1 groups were performed.

2023-04-30 | GSE229347 | GEO

Project description:Allergen exposure was thought to play a critical role in the etiology of AR. And allergen avoidance, the practice of avoiding exposure to allergens, has been generally advised as the management of AR. However, the effect is uncertain and the underlying mechanism is far from known. We used gene expression microarrays to identify genes differentially regulated by allergen avoidance in allergic rhinitis mouse model.

2013-11-28 | GSE52804 | GEO

Immunomodulatory Effect of Mesenchymal Stem Cell-Derived Exosomes Locally Delivered using PLGA Nanoparticles for the Treatment of Allergic Rhinitis

Project description:Immunomodulatory effect of MSC-derived exosomes in allergic Rhinitis

2023-11-01 | PXD046568 |

Therapy of allergic rhinitis using ribavirin spray to clear nasal commensal viruses

Project description:For analyzing the exploratory nasal commensal viruses, we performed the metatranscriptomic analysis of the nose swabs from the enrolled AR patients both before and after treatments, as well as sequenced the nose swabs from a set of healthy volunteers without AR history.Simultaneously, to assess the expression of interferon-stimulated genes in patients with allergic rhinitis, we analyzed the gene expression of host reads.

2024-08-21 | GSE275114 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data