Project description:description Blastocystis sp. is a highly prevalent anaerobic eukaryotic parasite of humans and animals. The genome of several representatives has been sequenced revealing specific traits such as an intriguing 3’-end processing of primary transcripts. We have acquired a first high-throughput proteomics dataset on the difficult to cultivate ST4 isolate WR1 and detected 2,761 proteins. We evidenced for the first time by proteogenomics a functional termination codon derived from transcript polyadenylation for seven different key cellular components.

2017-09-11 | PXD006588 | Pride

Embleya hyalina strain:NBRC 13850

Project description:Embleya hyalina genome project

| PRJDB7738 | ENA

Embleya scabrispora strain:NF3

Project description:Embleya scabrispora strain:NF3 Genome sequencing and assembly

| PRJNA377273 | ENA

Embleya scabrispora DSM 41855

Project description:Embleya scabrispora DSM 41855 Genome sequencing and assembly

| PRJNA165453 | ENA

Bacteroidetes MST

Project description:Bacteroidetes pyrosequencing for microbial source tracking (MST)

| PRJEB2468 | ENA

Methanosarcina thermophila MST-A1

Project description:Methanosarcina thermophila MST-A1

| PRJDB14919 | ENA

MST-312: a telomerase inhibitor effectively blocking MYC oncogenic functions [array]

Project description:Reactivation of the telomerase reverse transcriptase subunit, TERT, is linked to tumourigenesis due to well-documented telomere-dependent and independent functions. The aim of this study was to investigate the effect of the telomerase inhibitor, MST-312, on TERT functions, focusing in particular, on its effects on MYC stabilty and MYC-regulated pathways, in order to assess its potential as a therapeutic agent. We demonstrate that MST-312 reduces MYC levels in cancer cells, leading to reduced MYC levels on chromatin, and subsequently affecting the MYC-regulated transcriptional program. As a result, MST-312 treatment increases the survival of lymphoma-bearing mice. Mechanistically, MST-312 affects the conformation of TERT, leading to TERT/Terc dissociation, and the subsequent loss of both its telomere-dependent and independent functions. Based on the presented data, we conclude that MST-312 treatment is a promising therapeutic strategy, in particular, in MYC-driven tumorus.

2020-01-01 | GSE77014 | GEO

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