Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pichia kudriavzevii

ABSTRACT: Pichia kudriavzevii Transcriptome or Gene expression

PROVIDER: PRJNA1222276 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32319401.fastq.gz	Fastqsanger.gz
	SRR32319402.fastq.gz	Fastqsanger.gz
	SRR32319403.fastq.gz	Fastqsanger.gz
	SRR32319404.fastq.gz	Fastqsanger.gz
	SRR32319405.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Pichia kudriavzevii

Project description:Pichia kudriavzevii Genome sequencing

| PRJNA922718 | ENA

Pichia kudriavzevii

Project description:Pichia kudriavzevii Genome sequencing

| PRJNA1018555 | ENA

Pichia kudriavzevii

Project description:Global studies of Pichia kudriavzevii

| PRJNA792690 | ENA

Pichia kudriavzevii

Project description:Pichia kudriavzevii Raw sequence reads

| PRJNA1242297 | ENA

Pichia kudriavzevii

Project description:Pichia kudriavzevii Genome sequencing and assembly

| PRJNA770173 | ENA

Pichia kudriavzevii

Project description:Pichia kudriavzevii Genome sequencing and assembly

| PRJNA369592 | ENA

Genomic analyses reveal high diversity and rapid evolution of Pichia kudriavzevii within a neonatal intensive care unit in Delhi, India

Project description:Pichia kudriavzevii causes life-threatening infections in immune compromised hosts including hospitalized neonates. This pathogen is resistant to fluconazole while uncommon, strains resistant to multiple antifungal drugs voriconazole, amphotericin B and echinocandins have been reported in healthcare environments. Understanding how P. kudriavzevii spread, persist, and adapt to healthcare settings could help us develop better management strategies. In this study, whole genome sequencing identifies multiple outbreaks of bloodstream infections caused by P. kudriavzevii in a single neonatal intensive care unit (NICU) over five years. Interestingly, two genetically diverse clusters of P. kudriavzevii population showed frequent loss of heterozygosity (LOH) events between two temporal samples. The first outbreak cluster (during 2015-16) showed LOH at chromosomes 1, 4 and 5 and the other outbreak cluster (year 2020) exhibited marked LOH at chromosome 2. The circulation of two separate strain clusters of P. kudriavzevii suggests nosocomial transmission in the NICU in different time periods. Further, to evaluate the gene expression difference between isolates from two clusters, we compared the transcriptomic profiles of three isolates of cluster I and II and exhibiting distinct fluconazole MICs. While no difference was found at the azole target gene ERG11 or the ATP-binding cassette (ABC) transporter genes, differences in transcript abundance were found between the two isolates in genes coding for cell division and filamentation, repressor of ABC gene, FCR1 and ERG5 gene involved in ergosterol biosynthesis pathway. Our study indicates significant diversity, persistence, and rapid evolution of P. kudriavzevii within a single NICU.

2024-12-16 | GSE282019 | GEO

Pichia kudriavzevii M12

Project description:Pichia kudriavzevii M12 Genome sequencing and assembly

| PRJNA171021 | ENA

Metabolic engineering of the acid-tolerant yeast Pichia kudriavzevii for efficient L-malic acid production at low pH

Project description:Soluble pyridine nucleotide transhydrogenase (EcSthA) derived from Escherichia coli was introduced into the L-malic acid producing strain MA009-5 of Pichia kudriavzevii to obtain strain MA009-10. It was found that MA009-10 was superior to MA009-5 in terms of L-malic acid titer, glucose consumption rate, and glucose/L-malic acid conversion rate. To elucidate the effect of EcSthA expression on L-malic acid synthesis, we analyzed the RNA-seq data of both strains.

2023-05-03 | GSE202655 | GEO

Pichia kudriavzevii strain:yHQL191

Project description:Pichia kudriavzevii yHQL191 Resequencing genome sequencing

| PRJNA619058 | ENA