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Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K.

ABSTRACT: Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K.

PROVIDER: PRJNA1222325 | ENA |

REPOSITORIES: ENA

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Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K. (RNA-seq)

Project description:Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K. (RNA-seq)

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Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K. (ChIP-seq)

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Non-enzymatic SETD1A activity drives breast cancer cell proliferation via cyclin K. (RNA-seq)

Project description:Breast cancer is the most common cancer in women worldwide. SETD1A, a histone H3 lysine-4 methyltransferase, is associated with poor prognosis in breast cancer. While both its enzymatic and non-enzymatic functions have been implicated in cancer progression, the specific role of SETD1A in breast cancer remains unclear. This study aimed to elucidate the molecular mechanisms underlying SETD1A dependency in breast cancer.

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A non-catalytic function of SETD1A regulates Cyclin K and the DNA damage response [RNA-seq]

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Project description:This SuperSeries is composed of the SubSeries listed below.

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SETD1A function is mediated through interaction with mitotic regulators BuGZ/BUB3 in leukemia [ChIP-seq]

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