Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mycobacterium tuberculosis

ABSTRACT: Whole genome sequencing data for the Centralized clinical trial sponsored by FIND

PROVIDER: PRJNA1222624 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32327300_1.fastq.gz	Fastqsanger.gz
	SRR32327300_2.fastq.gz	Fastqsanger.gz
	SRR32327400_1.fastq.gz	Fastqsanger.gz
	SRR32327400_2.fastq.gz	Fastqsanger.gz
	SRR32327500_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 1046

Similar Datasets

Mycobacterium tuberculosis

Project description:WGS and pDST data from the XDR clinical trial of FIND

| PRJNA1087582 | ENA

Mycobacterium tuberculosis

Project description:Seq&Treal Phase II clinical trial results

| PRJNA1160005 | ENA

Mycobacterium tuberculosis microarray to screen anti-tuberculosis compounds

Project description:Feature reduction of microarray data from mycobacteria treated with a variety of various clinical and investigational drugs We are using feature reduction to demonstrate that subsets of biomarker genes representative of the whole genome are sufficient for MOA classification and deconvolution in a medium-throughput microfluidic format ultimately leading to a cost effective and rapid tool for routine antibacterial drug-discovery programs.

2013-04-24 | E-GEOD-46212 | biostudies-arrayexpress

Mycobacterium tuberculosis tween supernatants

Project description:Whole cell lysates of THP-1 macrophages infected with of M. tuberculosis CDC1551, a ppe38-ppe71 knock out mutant and a complemented strain was performed at 4h and 18h post infection to find the differentially regulated proteins.

2021-06-15 | PXD021167 | Pride

Mycobacterium tuberculosis

Project description:Whole genome sequence of M. tuberculosis clinical isolates with resistant to clofazimine

| PRJNA395592 | ENA

Mycobacterium tuberculosis

Project description:Whole genome sequencing and transcriptome analysis of Mycobacterium tuberculosis clinical isolates from Bovine and Human origin

| PRJNA512047 | ENA

Mycobacterium tuberculosis

Project description:Mycobacterium tuberculosis whole genome sequencing

| PRJNA283583 | ENA

A multicenter translational biomarker phase II trial of regorafenib in patients with non-resectable pretreated colorectal cancer.

Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS). Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).

| 2533916 | ecrin-mdr-crc

Identification of gene fusion events in Mycobacterium tuberculosis that encode novel chimeric proteins

Project description:Mycobacterium tuberculosis is a facultative intracellular pathogen, responsible for causing tuberculosis. The harsh environment in which M. tuberculosis survives requires this pathogen to maintain an evolutionary advantage. However, the apparent absence of horizontal gene transfer in M. tuberculosis imposes restrictions in the ways by which evolution can occur. Large scale changes in the genome can be introduced through genome reduction, recombination events and structural variation. Here, we identify a functional chimeric protein in the ppe38-71 locus, the absence of which is known to have an impact on protein secretion and virulence. To examine whether this approach was used more often by this pathogen we further develop software that detects potential gene fusion events from multigene deletions using whole-genome sequencing data. With this software we could identify a number of other putative gene-fusion events within the genomes of M. tuberculosis isolates. We were able to demonstrate the expression of one of these gene fusions at the protein level using mass spectrometry. Therefore, gene fusions may provide an additional means of evolution for M. tuberculosis in its natural environment whereby novel proteins and functions can arise.

2020-05-12 | PXD017298 | Pride

Mycobacterium tuberculosis microarray to screen anti-tuberculosis compounds

Project description:Feature reduction of microarray data from mycobacteria treated with a variety of various clinical and investigational drugs

2013-04-24 | GSE46212 | GEO