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Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis [ZE309]

ABSTRACT: Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis [ZE309]

PROVIDER: PRJNA1223415 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32332900.fastq.gz	Fastqsanger.gz
	SRR32332901.fastq.gz	Fastqsanger.gz
	SRR32332902.fastq.gz	Fastqsanger.gz
	SRR32332903.fastq.gz	Fastqsanger.gz
	SRR32332904.fastq.gz	Fastqsanger.gz

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Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis.

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Project description:Immunoglobulin A (IgA) is the predominant immunoglobulin isotype in mammals, primarily secreted at type I mucosal surfaces. Despite its abundance, the precise role of secretory IgA in the intestinal lumen, where it coats a diverse array of commensal microbiota, has remained elusive. Our study reveals that germinal center IgA responses are essential for preventing chronic colonization of the gut by specific viruses. In absence of IgA, chronic viral colonization triggers an antigen-driven expansion of CD8αβ+ intraepithelial lymphocytes (IELs). Although, these IELs are unable to clear the virus, they contribute to maintaining homeostasis by regulating its load and type-I interferon responses. Consequently, IgA deficiency increases susceptibility to colitis in genetically susceptible host or following chemical induction, but only in presence of viral pathobionts requiring IgA for their clearance. These findings underscore the potential vulnerability of IgA deficient individuals to immunopathology when exposed to selective viral pathobionts.

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Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing.

Project description:RNAseq analysis of caecal tissue from 14 C. jejuni-susceptible and 14 C. jejuni-resistant birds from a single population of infected chickens was conducted in order to identify gene expression associated with resistance to colonization. Significantly higher expression of genes involved in the innate immune response, cytokine signaling, B cell and T cell activation and immunoglobulin production, as well as the renin-angiotensin system was observed in resistant birds. A population of 255 Barred Rock chickens were orally inoculated with C. jejuni and their caecal colonization levels estimated 48 hours post-inoculation. Caecal samples from 14 birds with no colonization and the 14 birds with the highest colonization were selected for mRNA sequencing.

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