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Campylobacter jejuni subsp. jejuni 81-176

ABSTRACT: Campylobacter jejuni Transcriptome

PROVIDER: PRJNA1223640 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32341600_1.fastq.gz	Fastqsanger.gz
	SRR32341600_2.fastq.gz	Fastqsanger.gz
	SRR32341592_1.fastq.gz	Fastqsanger.gz
	SRR32341592_2.fastq.gz	Fastqsanger.gz
	SRR32341593_1.fastq.gz	Fastqsanger.gz

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Transcriptomic changes of Campylobacter jejuni subsp. jejuni strain 81-176 in water

Project description:Campylobacter jejuni is the leading cause of campylobacteriosis in the developed world. Although most cases are caused by consumption of contaminated meat, a significant proportion is caused by consumption of contaminated water. Some C. jejuni isolates are better than others at surviving in water, which suggests that these strains are better adapted to transmission by water than others. The aim of this study is to investigate this phenomenon further. CFU counts and viability assays showed that strain 81116 survives better than strain 81-176 in a defined freshwater medium at 4°C. Comparative transcriptomic profiling using microarray revealed that these strains respond differently to water. This series presents the transcriptome of strain 81-176 in water.

2017-09-01 | GSE94929 | GEO

Campylobacter jejuni subsp. jejuni 81-176

Project description:Campylobacter jejuni subsp. jejuni 81-176 Genome sequencing

| PRJNA213222 | ENA

Campylobacter jejuni subsp. jejuni 81-176

Project description:Campylobacter jejuni subsp. jejuni 81-176 Raw sequence reads

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Campylobacter jejuni subsp. jejuni 81-176

Project description:Transcriptomic changes of Campylobacter jejuni subsp. jejuni strain 81-176 in water

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Campylobacter jejuni subsp. jejuni 81-176

Project description:Campylobacter jejuni subsp. jejuni 81-176 RNA-Seq in culture, during infection of chicks

| PRJNA210752 | ENA

Campylobacter jejuni subsp. jejuni 81-176-UMCW7

Project description:Campylobacter jejuni subsp. jejuni 81-176-UMCW7 Genome sequencing and assembly

| PRJNA230835 | ENA

Campylobacter jejuni subsp. jejuni 81-176-DRH212

Project description:Campylobacter jejuni subsp. jejuni 81-176-DRH212 Genome sequencing and assembly

| PRJNA230832 | ENA

Campylobacter jejuni subsp. jejuni 81-176-UMCW9

Project description:Campylobacter jejuni subsp. jejuni 81-176-UMCW9 Genome sequencing and assembly

| PRJNA230836 | ENA

Campylobacter jejuni subsp. jejuni 81-176

Project description:Role of DksA in the pathogenesis and physiology of Campylobacter jejuni.

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Transcriptional profile in the macrolide resistant C. jejuni strains selected from 81-176

Project description:Campylobacter, a major foodborne pathogen, is increasingly resistant to macrolide antibibotics. previous findings suggeted that development of macrolide resistance in campylobacter requires a multi-step process, but the molecular mechanisms involved in the process are not known. In our study, multiple seriess of macrolide-resistant C. jejuni mutants were selected in vitro by stepwise exposure of C. jejuni 81-176 to increasing concentrations of erythromycin and tylosin. A set of the selected resistance were subjected to microarray and the the global transcriptional profile was analyzed. In this sery, DNA microarray was used to compare the gene expression profiles of macrolide resistant strains (76E2, 76E8 and 76E64) with its parent wild-type strain C. jejuni 81-176. This assay identified a large number of genes that showed >1.5 fold changes (q-value<0.1) in expression in the macrolide resistant strains. The up-regulated genes are involved in surface structure,ribosomal, heat shock and some specific Misc memerbrane , while the majority of the down-regulated genes are involved in energy metabolism, amino acid biosynthesis. The over-expression of genes involved in surface structure and Misc memerbrance was associated with the development of intermedial-level resistance to macrolide in campylobacter 81-176. Keywords:intermedial-level macrolide resistant C. jejuni selected from C. jejuni 81-176. step-wise selection.

2010-12-28 | GSE17899 | GEO

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