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Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia [scATAC-seq]

ABSTRACT: Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia [scATAC-seq]

PROVIDER: PRJNA1225192 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32384711_1.fastq.gz	Fastqsanger.gz
	SRR32384711_2.fastq.gz	Fastqsanger.gz
	SRR32384712_1.fastq.gz	Fastqsanger.gz
	SRR32384712_2.fastq.gz	Fastqsanger.gz
	SRR32384713_1.fastq.gz	Fastqsanger.gz

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Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia [scATAC-seq]

Project description:Pediatric cancers are increasingly linked to transformation events before birth, yet how ontogeny influences oncogenesis remains poorly understood. Using a humanized model of NUP98-NSD1-driven pediatric acute myeloid leukemia, particularly aggressive when accompanied by WT1 mutations, we investigated how the developmental stage of hematopoietic stem cells impacts leukemic transformation, disease progression and therapy response. Fetal-derived hematopoietic stem cells readily transform into leukemia, with WT1 mutations enhancing stemness and alter lineage hierarchy, while stem cells from later developmental stages progressively withstand transformation. Single-cell analyses revealed that fetal-origin versus postnatal leukemic stem cells exhibit greater quiescence and metabolic reliance on oxidative phosphorylation. Notably, therapeutic responses markedly differed between fetal- and postnatal-origin leukemias, even when driven by the same oncogenic mutations. In patients, onco-fetal transcriptional programs were associated with worse outcomes. We identified tailored combination therapies that specifically diminished aggressive fetal-origin leukemia, underscoring the need to consider ontogeny in treatment of pediatric cancers.

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Project description:In a classical view of hematopoiesis, the various blood cell lineages arise via a hierarchical scheme starting with multipotent stem cells that become increasingly restricted in their differentiation potential through oligopotent and then unipotent progenitors. We developed a cell-sorting scheme to resolve myeloid (My), erythroid (Er), and megakaryocytic (Mk) fates from single CD34+ cells and then mapped the progenitor hierarchy across human development. Fetal liver contained large numbers of distinct oligopotent progenitors with intermingled My, Er and Mk fates. However, few oligopotent progenitor intermediates were present in the adult bone marrow. Instead only two progenitor classes predominate, multipotent and unipotent, with Er-Mk lineages emerging from multipotent cells. The developmental shift to an adult 'two-tier' hierarchy challenges current dogma and provides a revised framework to understand normal and disease states of human hematopoiesis.

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