Project description:Epidemiological data indicate that strains MGAS315 and MGAS9887 differ significantly in their capacity to cause necrotizing fasciitis infections. To probe the hypothesis that this difference was associated with differences in gene expression, an expression MA comparison of the strains in exponential phase growth in rich media was conducted. Keywords: strain comparison
2006-02-28 | GSE3966 | GEO
Project description:16S rDNA sequencing of necrotizing fasciitis samples
Project description:Free fatty acids (FA) secreted by the sebaceous glands are a critical component of the skin barrier. Here, we investigate the activity of the major FA species present in the skin against Streptococcus pyogenes (group A Streptococcus; GAS), a major cause of skin infections such as impetigo, erysipelas, cellulitis, and necrotizing fasciitis. Several relevant FAs had antimicrobial activity against GAS and induced differential regulation of GAS virulence factors.