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Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

ABSTRACT: Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

PROVIDER: PRJNA1227462 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32465950_1.fastq.gz	Fastqsanger.gz
	SRR32465950_2.fastq.gz	Fastqsanger.gz
	SRR32465951_1.fastq.gz	Fastqsanger.gz
	SRR32465951_2.fastq.gz	Fastqsanger.gz
	SRR32465952_1.fastq.gz	Fastqsanger.gz

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Drosophila Hamlet mediates epithelial tissue assembly of the reproductive system

Project description:Epithelial tissue fusion requires coordinated molecular events at the ends of two epithelial structures. Regulatory mechanisms controlling these events remain largely elusive. In the Drosophila reproductive system (RS), this fusion unites the gonad and the genital disc-derived tissues, into a continuous tube. This study unveils the pivotal role of Hamlet (Ham), a Drosophila PR-domain containing transcription factor, in orchestrating epithelial tissue fusion in the RS. Loss of ham leads to sterility and disconnection between the testes (TE) and seminal vesicles (SV). Systematic analysis of Ham-downstream genes reveals cytoskeletal, metabolic regulators and signaling pathway components. Ham activates genes for epithelial differentiation and remodeling, while repressing genes required for tissue growth and patterning. Using multiplexed in situ hybridization, we demonstrate spatial-temporal gene expression dynamics in contacting epithelia. Key Ham downstream effectors include E-Cadherin (E-Cad), Toll (Tl) and Wnt2 signaling pathways, regulating tissue interaction and fusion. Our findings present a comprehensive gene network crucial for heterotypic epithelial tissue fusion. Mammalian Ham orthologs PRDM3 and PRDM16 are highly expressed in epithelial tissues, suggesting a conserved role across species.

2025-03-21 | GSE290310 | GEO

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