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Riclin: A novel soluble dietary fiber for promoting gastric health and ameliorating gastric mucosal injury

ABSTRACT: Riclin: A novel soluble dietary fiber for promoting gastric health and ameliorating gastric mucosal injury

PROVIDER: PRJNA1230083 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32538727_1.fastq.gz	Fastqsanger.gz
	SRR32538727_2.fastq.gz	Fastqsanger.gz
	SRR32538728_1.fastq.gz	Fastqsanger.gz
	SRR32538728_2.fastq.gz	Fastqsanger.gz
	SRR32538729_1.fastq.gz	Fastqsanger.gz

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Riclin: A novel soluble dietary fiber for promoting gastric health and ameliorating gastric mucosal injury

Project description:Focal and diffuse damage to the gastric mucosa contributes to gastric mucosal injury (GMI). Dietary fiber may exert protective effects against GMI; however, its use as a gastrointestinal intervention remains limited. Here, we assessed the potential role of dietary fiber Riclin in GMI. Dietary fiber Riclin exerted a dual effect in enhancing gastric mucosal defense. It modulated microbial-metabolite composition, enhancing biological barriers and reinforcing sustained adhesion to the gastric mucus bicarbonate barrier. Additionally, Riclin enhanced the gastric mucosal immune barrier through the NOD/TLR4/NF-κB pathway. The protective role of Riclin in GMI was revealed by constructing an alcohol-induced murine gastric ulcer model. Our results propose Riclin as a novel dietary fiber with the potential to ameliorate a wide range of gastric disorders characterized by a disrupted gastric mucosal defense and immune dysregulation. In particular, we underscore its potential as a promising dietary fiber for promoting gastric health.

2025-03-15 | GSE290768 | GEO

Water-soluble dietary fiber alleviates cancer-induced muscle wasting through changes in gut microenvironment in mice

Project description:Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that the pathogenesis of skeletal muscle loss may involve dysbiosis of the gut microbiota and the accompanying chronic inflammation or altered metabolism. In this study, we evaluated the possible effects of modifying the gut microenvironment with partially hydrolyzed guar gum (PHGG), a soluble dietary fiber, on cancer-related muscle wasting and its mechanism using a colon-26 murine cachexia model. Compared to a fiber-free (FF) diet, PHGG contained fiber-rich (FR) diet attenuated skeletal muscle loss in cachectic mice by suppressing the elevation of the major muscle-specific ubiquitin ligases Atrogin-1 and MuRF1, as well as the autophagy markers LC3 and Bnip3. Although tight junction markers were partially reduced in both FR and FF diet-fed cachectic mice, the abundance of Bifidobacterium, Akkermansia, and unclassified S24-7 family increased by FR diet, contributing to the retention of the colonic mucus layer. The reinforcement of the gut barrier function resulted in the controlled entry of pathogens into the host system and reduced circulating levels of lipopolysaccharide-binding protein (LBP) and IL-6, which in turn led to the suppression of proteolysis by downregulating the ubiquitin-proteasome system and autophagy pathway. These results suggest that dietary fiber may have the potential to alleviate skeletal muscle loss in cancer cachexia, providing new insights for developing effective strategies in the future.

2021-11-23 | E-MTAB-11094 | biostudies-arrayexpress

Impact of Dietary Fiber Supplementation on Colonic Mucosal Microbiome

Project description:This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health. Certain microbial strains are associated with the growth of colon polyps, which eventually could go on to form colon cancer. Giving dietary fiber supplements may help prevent precancerous polyps from ever developing.

| 1864 | ecrin-mdr-crc

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Project description:Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

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Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

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The role of dietary fiber in microglial transcriptome

Project description:To understand how dietary fiber affects microglial transcriptome at early stage, we fed mice diets releasing different amount of fiber and profiled microglia at 3 weeks. We found that fiber significantly altered the transcriptomic signature of microglia.

2023-09-08 | GSE186210 | GEO

Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial

Project description:The investigators hypothesize that an increase in dietary fiber intake during radiation therapy may provide better long-term intestinal health for the cancer survivor. If the hypothesis is not correct, the increased intake may only mean an increase in acute side effects. All participants are advised to consume at least 16 g of dietary fiber/day via food. In addition, participants are invited to take capsules that together contain either 5.5 g of dietary fiber from psyllium husk or placebo.

| 2350423 | ecrin-mdr-crc

Castor fiber fiber

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Human gastric mucosal samples

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| PRJNA656070 | ENA

dupA+ gastric mucosal microbiome

Project description:dupA+ gastric mucosal microbiome Raw sequence reads

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