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Emergence of essential functions of a transcription factor in the cyanobacterium Nostoc/Anabaena sp. PCC 7120 [ChIP-seq]

ABSTRACT: Emergence of essential functions of a transcription factor in the cyanobacterium Nostoc/Anabaena sp. PCC 7120 [ChIP-seq]

PROVIDER: PRJNA1231564 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32570054.fastq.gz	Fastqsanger.gz
	SRR32570054_1.fastq.gz	Fastqsanger.gz
	SRR32570054_2.fastq.gz	Fastqsanger.gz
	SRR32570055.fastq.gz	Fastqsanger.gz
	SRR32570055_1.fastq.gz	Fastqsanger.gz

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Emergence of essential functions of a transcription factor in the cyanobacterium Nostoc/Anabaena sp. PCC 7120 [ChIP-seq]

Project description:How new functions emerge as genes diversify during evolution is an important question in biology. cyclic adenosine monophosphate receptor protein (CRP) -type transcription factors are widespread in bacteria, often with several members coexisting in the same organism. How do they achieve functional specificity with highly conserved structures? In the filamentous cyanobacterium Nostoc/Anabaena sp. PCC 7120, both NtcA and DevH belong to the CRP family, yet DevH is essential while NtcA is not. Together with previously published data, we demonstrate here that ntcA and devH mutually and positively regulate each other for enhanced expression. Furthermore, NtcA and DevH share a common consensus DNA binding site, and both of them exert global regulation functions for metabolism, photosynthesis and cell development. We show that compared to NtcA, DevH achieved functional specificity and essentiality by structural innovations and increased cellular concentrations, leading to a stronger and broader regulatory function independent of allosteric control. Based on our data, we propose a model on how these two conserved transcription factors provide both overlapping and distinct regulatory functions, to better coordinate transcriptional activities under different conditions. This study constitutes an example illustrating how functional divergence can be achieved following gene diversification of transcription factors, leading to increased complexity in gene regulation networks.

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Identification of the global transcriptional regulator All3953 (RbcR) in the cyanobacterium Anabaena sp. PCC 7120 by ChIP-Seq analysis

Project description:The whole regulon of the LTTR All3953 was determined at 3 h after Ci deficiency in the cyanobacterium Anabaena sp. PCC 7120 by ChIP-Seq analysis. A TAP-tagged version of the protein was used for the chromatin immunoprecipitation. A total of 142 peaks were found, mainly located in the chromosome of Anabaena.

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Effect of devH deprivation on gene expression in the cyanobacterium Nostoc/Anabaena sp. PCC 7120 [RNA-seq]

2025-03-07 | GSE291106 | GEO

Transcriptional Regulation of Anabaena 7120 response to Nitrogen Deprivation

2011-06-22 | GSE26633 | GEO

Nostoc sp. PCC 7120 = FACHB-418

Project description:RNA-seq of Cyanobacterium Anabaena sp. Strain PCC 7120

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Effect of deletion of all0854 on gene expression of Nostoc sp. PCC 7120

Project description:To investigate the function of All0854, we constructed the all0854 deletion mutant Mall0854, in which all0854 was knocked out by CRISPER-cpf1. We then performed gene expression profiling analysis using data obtained from RNA-seq of wide type Nostoc sp. PCC 7120 and Mall0854.

2023-05-01 | GSE218875 | GEO

Effect of devH deprivation on gene expression in the cyanobacterium Nostoc/Anabaena sp. PCC 7120 [RNA-seq]

Project description:Effect of devH deprivation on gene expression in the cyanobacterium Nostoc/Anabaena sp. PCC 7120 [RNA-seq]

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Transcriptional Regulation of Anabaena 7120 response to Nitrogen Deprivation

Project description:Here, we report the transcriptome of Anabaena sp. strain 7120, a cyanobacterium that forms specialized nitrogen-fixing cells called heterocysts. Our data suggests that cyanobacteria frequently have more complex transcripts than thought, with large 5' UTRs, numerous antisense transcripts, and multiple transcriptional start sites or processing sites. Four samples of total filament RNA were sequenced with Illumina 40bp reads using directional RNA sequencing (see the Illumina small RNA prep protocol). The samples are 0hr (vegetative cells grown in the presence of ammonia) and 6hr, 12hr, and 21hr cells (after nitrogen step down).

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RNA-seq of Nostoc sp. PCC 7120 (Anabaena sp. PCC 7120) wild-type strain, hetZ mutant and hetP mutant

Project description:Total RNA was extracted from Anabaena 7120, hetZ mutant and hetP mutant at 24 h after nitrogen stepdown with two independent biological replicates. To maintain the integrity of coding RNAs, total RNA were sequenced without ribosomal RNA elimination. Strand-specific RNA-Seq libraries were prepared and sequenced using the Illumina HiSeq 2500 sequencing instrument to generate paired-end reads with length of 125 bp.

2018-02-19 | E-MTAB-6459 | biostudies-arrayexpress

Nostoc sp. PCC 7120 = FACHB-418

Project description:Nostoc sp. PCC 7120 Transcriptome

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