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Blimp-1 protects the transcriptional identity of group 2 innate lymphocytes in lung inflammation [ATAC-seq]

ABSTRACT: Blimp-1 protects the transcriptional identity of group 2 innate lymphocytes in lung inflammation [ATAC-seq]

PROVIDER: PRJNA1232619 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32589052_1.fastq.gz	Fastqsanger.gz
	SRR32589052_2.fastq.gz	Fastqsanger.gz
	SRR32589053_1.fastq.gz	Fastqsanger.gz
	SRR32589053_2.fastq.gz	Fastqsanger.gz
	SRR32589054_1.fastq.gz	Fastqsanger.gz

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IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma

Project description:IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma

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IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma [RNA-seq]

Project description:Type 2 inflammation in the lung underlies allergic asthma and promotes tumor metastasis. Type 2 innate lymphoid cells (ILC2s) respond to tissue damage signals including IL-33 and IL-25 and are implicated in type 2 inflammatory diseases of the lung, but the factors that maintain ILC2s ability to produce type 2 cytokines are not known. We show Blimp-1 is a key transcriptional repressor of type 1 genes induced by the type 2 cytokine IL-9 in ILC2s in response to tissue damage signals. Loss of Blimp-1 in ILC2s altered inflammation in response to allergens, but also limited metastatic melanoma in the lung by limiting type 2 cytokines in favor of type I cytokines including IFNg and TNF. Thus, Blimp-1 protects the type 2 identity of ILC2s during lung inflammatory diseases.

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IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma [ATAC-seq]

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IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma [RNA-seq]

Project description:IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma [RNA-seq]

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IL-9 and Blimp-1 protects the transcriptional identity of group 2 innate lymphocytes in allergic asthma

Project description:Allergic asthma is driven by type 2 immune responses, including those mediated by type 2 innate lymphoid cells (ILC2s). Although ILC2s are activated by the tissue alarmins IL-33 and IL-25, these signals do not intrinsically enforce type 2 identity, and the mechanisms that maintain type 2 cytokine expression remain unclear. Here we show that allergen-induced IL-33 and IL-25 rapidly induce IL-9, which in turn upregulates the transcriptional repressor Blimp-1 in ILC2s. Blimp-1 sustains type 2 immunity by directly repressing type 1 inflammatory programs, including expression of IFNg and TNF. Deletion of Blimp-1 in ILC2s increased type 1 cytokine production and reduced IL-5 and IL-13 expression, eosinophil recruitment, and mucus production in the lung. In contrast, IL-9 expression was enhanced in the absence of Blimp-1, leading to increased mast cell recruitment. Together, these findings identify Blimp-1 as a key regulator of ILC2 transcriptional fidelity that stabilizes type 2 inflammation while constraining divergent inflammatory programs during allergic responses.

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Project description:In this study we present the first genome-wide expression profiling of peripheral B cells by massive parallel RNA sequencing in patients with allergic asthma validating the discovery potential of this approach in allergy. RNA-seq was used to asses expression differences in B CD19 Lymphocytes from house dust mite allergic patients and healthy controls.

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IL-9 and Blimp-1 protects the transcriptional identity of group 2 innate lymphocytes in allergic asthma

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