Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Decidual ESF co-culture with primary EVTs

ABSTRACT: Decidual ESF co-culture with primary EVTs

PROVIDER: PRJNA1235293 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Decidual ESF co-culture with primary EVTs

Project description:Endometrial Stromal Fibroblasts, Decidualized Endometrial Stromal Fibroblasts (dESF), Extravillious Trophoblasts (EVTs) and co-cultured EVTs and dESFs

2025-08-19 | GSE291820 | GEO

Primary prostate organoid transcriptomic profile in co-culture with primary prostate stroma

Project description:Primary prostate organoid transcriptomic profile in co-culture with primary prostate stroma

| PRJNA473572 | ENA

Primary prostate organoid transcriptomic profile in co-culture with primary prostate stroma

Project description:Organotypic in vitro culture is useful to model mammalian disease in numerous tissues. Normal epithelial differentiation and carcinogenesis both undergo in vivo regulation by stroma, but current culture methods exclude stroma. To mimic this in vivo environment, we developed and characterized a human 3D prostate organoid co-culture model that incorporates prostate stroma. Primary prostate stromal cells supported increased organoid formation and expressed growth factors and WNT-related genes involved in epithelial differentiation. Organoid branching occurred distal to physical contact with stromal cells, demonstrating non-random branching. Tumoroids derived from primary prostate cancer maintained differential expression of the prostate cancer marker AMACR only in the presence of stroma. Stroma-induced phenotypes were similar in all patients examined, yet maintained inter-patient heterogeneity in the degree of response. Addition of stroma to in vitro organoid culture recapitulated the in vivo microenvironment by inducing organization of benign organoids into branching structures and preserving prostate cancer phenotypes.

2018-05-30 | GSE115052 | GEO

Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection

Project description:A Toxoplasma gondii infection during pregnancy can result in spontaneous abortion, preterm labor, or congenital fetal defects. The decidual immune system plays a critical role in regulating the immune micro-environment and in the induction of immune tolerance. To better understand the factors that mediate the decidual immune response associated with the T. gondii infection, a large-scale study employing TMT proteomics was conducted to characterize the differential decidual immune proteomes from infected and uninfected human decidual immune cells samples. The decidual immune cells from 105 human voluntary abortion tissues were purified, and of the 5510 unique proteins identified, 181 proteins were found to be differentially abundant (>1.2-fold cutoff, P＜0.05) in the T. gondii-infected decidual immune cells. 11 proteins of 181 differentially expressed proteins associated with trophoblast invasion, placental development, intrauterine fetal growth, and immune tolerance were verified using a quantitative real-time polymerase chain reaction and western blotting. This systematic research identified a broad range of immune factors in human decidual immune cells, shedding a new insight into the decidual immune molecular mechanism for abnormal pregnancy outcomes associated with T. gondii infection.

2018-07-27 | PXD008448 | Pride

Acidophilic co-culture

Project description:Genomic and transcriptomic analysis of acidophilic co-culture

| PRJNA639692 | ENA

Microarray analysis of adipocyte co-culture with SKOv3ip1 cells

Project description:Analysis of gene expression in SKOv3ip1 cells with and without co-culture of human primary adipocytes. Hypothesis is that adipocyte co-culure changes lipid metabolism pathways in ovarian cancer cells.

2018-05-09 | GSE104237 | GEO

CUT&RUN analysis of murine wt NPCs grown in alone and in co-culture with primary brain microvascular endothelial cells

Project description:We previously established co-culture assay in which NPCs acquire phenotypic hallmarks of quiescence upon direct cell-cell contact with primary brain microvascular endothelial cells (bmvEC). Here, we used this in vitro assay to identify the mechanisms by which p53 enforces quiescence

2023-03-27 | GSE165802 | GEO

Human primary subcutaneous preadipocytes: Control vs PBMC co-culture

2010-12-03 | GSE19324 | GEO

Ketogulonigenium vulgare cells: co-culture mode vs. mono-culture mode

Project description:Ketogulonigenium vulgare cells: co-culture mode vs. mono-culture mode

| PRJNA162307 | ENA

Human primary subcutaneous preadipocytes: Control vs PBMC co-culture

Project description:Transcriptional profiling of human preadipocytes comparing preadipocytes cultured in control media vs co-culture with PBMC's after 3 days. Goal was to elucidate novel expression patterns in preadipocytes during exposure to human immune cells. 2-condition experiment, Preadipocytes+Media vs Preadipocytes+PBMC. Biological replicates: 4 experimental replicates.

2010-12-03 | E-GEOD-19324 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data