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ABSTRACT: CL stimulate endogenous simultaneous nitrifying and denitrifying pathways

PROVIDER: PRJNA1235608 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32680068_1.fastq.gz	Fastqsanger.gz
	SRR32680068_2.fastq.gz	Fastqsanger.gz
	SRR32680069_1.fastq.gz	Fastqsanger.gz
	SRR32680069_2.fastq.gz	Fastqsanger.gz
	SRR32680070_1.fastq.gz	Fastqsanger.gz

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Project description:In this study employed a systems analysis approach to study molecular signatures of cutaneous leishmaniasis (CL) caused by Leishmania tropica (L. tropica) in the skin lesions of ulcerativeCL (UCL) and non-ulcerative CL( NUCL) patients. Results from RNA-seq analysis determined shared and unique functional transcriptional pathways in the lesions of the UCL and Nucl patients. Several transcriptional pathways involved in inflammatory response were positively enriched in the CL lesions. These results enhance our understanding of human skin response to CL caused by L. tropica.

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Global changes in gene expression of buffalo cow corpus luteum during prostaglandin F2alpha- induced luteolysis

Project description:In monoovulatory species like bovines, a striking diversity in regulation of the corpus luteum (CL) function exists within species during different stages of the luteal phase. The function and life span of CL appears to be regulated by the interplay of both luteotrophic and luteolytic factors, whose roles and actions are varied from one species to another. Although, studies continue to expand our current understanding of the cellular and molecular actions of prostaglandin F 2alpha (PGF2α - a physiological luteolysin)-induced luteolysis, knowledge of the mechanism whereby, PGF2α mediates its luteolytic actions remains poorly understood. The mechanism of PGF2α-induced luteolysis is a complex process involving changes in expression of multiple genes encoding gene products that regulate steroidogenesis, stress related or apoptotic genes, factors involved in immune response and enzymes that stimulate PGF2α production. Thus, in the present study, efforts were made to identify the temporal changes in the global gene expression profile in the CL of buffalo cows in response to PGF2α treatment. The molecular signature of genome-wide transcriptional changes in the CL tissue subjected to PGF2α-induced luteolysis will expand our knowledge on basic mechanism/s that regulates the luteolytic process. The results obtained in this study provide insight into the mechanisms underlying the PGF2α- induced regression of CL.Keywords: CL, PGF2α, gene expression

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Downregulated Luteolytic Pathways in Early Pregnant Bovine CL: Mimicry by Interferon-tau in vitro

Project description:The downregulated pathways in early pregnant CL unraveled in this study span a wide range of luteal functions: angiogenesis, apoptosis and survival, steroidogenesis, and ECM remodeling. Notably, selective DEGs in luteinized granulosa cells (LGCs) were modulated by IFNT in vitro in a similar manner to their regulation in the CL of P cows, suggesting that IFNT may contribute to the characteristics of early pregnant CL.

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