Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Distinct molecular mechanisms of stress habituation in the mouse hippocampus [snATAC-seq]

ABSTRACT: Distinct molecular mechanisms of stress habituation in the mouse hippocampus [snATAC-seq]

PROVIDER: PRJNA1237688 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32752300_1.fastq.gz	Fastqsanger.gz
	SRR32752300_2.fastq.gz	Fastqsanger.gz
	SRR32752301_1.fastq.gz	Fastqsanger.gz
	SRR32752301_2.fastq.gz	Fastqsanger.gz
	SRR32752302_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 184

Similar Datasets

Distinct molecular mechanisms of stress habituation in the mouse hippocampus [snATAC-seq]

Project description:We explore how the tightly regulated molecular response triggered by acute restraint stress becomes altered after repeated restraint exposure. Transcriptomic sampling of the mouse hippocampus at multiple time points revealed that repeated stress leads to widespread habituation, damping stress-induced gene expression of all stress-responsive genes. However, we find no evidence for the emergence of new response profiles or alterations in baseline gene expression. Using single-cell multi-omics, we show that these findings hold true across cell types, and we reveal cell type specific patterns of habituation. Transcriptomic and chromatin accessibility profiles identify two distinct mechanisms that contribute to the observed habituation patterns: an early cAMP-associated mechanism that is related to blunted transcription after chronic stress, and a late corticosterone-dependent mechanism that is linked to a shortened transcriptional response.

2025-03-18 | GSE292225 | GEO