Project description:We collected whole genome testis expression data from hybrid zone mice. We integrated GWAS mapping of testis expression traits and low testis weight to gain insight into the genetic basis of hybrid male sterility.
Project description:The aim of this study was to assess whether chronic treatment with RPV can modulate the progression of chronic liver disease, especially of non-alcoholic fatty liver disease (NAFLD), through a nutritional model in wild-type mice Mice were daily treated with RPV (p.o.) and fed with normal or high fat diet during 3 months to induce fatty liver disease
Project description:To understand the effects of learning on expression in mouse striatum, we combined an automated operant conditioning chamber (OCC) setup with an efficient RNA-sequencing protocol. We compared 450 striatal expression profiles from 75 mice, e.g., the data contains 6 samples per mouse. Biopsies were taken from both hemispheres, three striatal regions (dorsoventral, dorsomedial, ventromedial striatum) at three learning stages (Early, Intermediate, Late). For each learning stage, there is the same number of samples from paired yoked control mice. There are also samples from control mice that were not kept in OCCs (Naive). The processed data can also be assessed and downloaded from here https://shiny.bio.lmu.de/Dopaloops/
Project description:To investigate the effects of the drug candidate CMS121 on transcrptional changes in the striatum of the R6/2 mouse model of Huntington's disease at 14 weeks of age.
Project description:Analysis of proteomic consequences of Tyrobp deletion in a Huntington's disease mouse model. Examination of protein expression alterations in the striatum of mutant huntingtin-Q175 with and without TYROBP (protein tyrosine kinase-binding protein).
2022-01-05 | MSV000088643 | MassIVE
Project description:Small RNA sequencing of striatum samples of the Huntington's disease mice model BACHD