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Transcriptional response to rotenone exposure in C. elegans and the effects on progeny

ABSTRACT: Transcriptional response to rotenone exposure in C. elegans and the effects on progeny

PROVIDER: PRJNA1238832 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17790300_1.fastq.gz	Fastqsanger.gz
	SRR17790300_2.fastq.gz	Fastqsanger.gz
	SRR17790301_1.fastq.gz	Fastqsanger.gz
	SRR17790301_2.fastq.gz	Fastqsanger.gz
	SRR17790294_1.fastq.gz	Fastqsanger.gz

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Effects of preconception exposure to rotenone on progeny depend on the degree of maternal toxicity

Project description:Parental exposure to toxicants can affect progeny health, including when those exposures occur prior to conception. However, most published preconception studies have involved exposures that result in loading of pollutants to gametes, or toxic effects to parents which could indirectly affect germ cell or gamete health. Here, we took advantage of the biology of Caenorhabditis elegans to carry out a preconception study in which we minimized the potential for maternal loading of toxicants, and used an exposure paradigm that either did (high concentration) or did not (low concentration) significantly impact the health of the P0 generation. We hypothesized that preconception exposure to mitochondrial toxicants (rotenone, and in some cases antimycin A or pyraclostrobin) during germ cell and gamete development, at levels not causing P0 toxicity, would impact mitochondrial processes in germ cells or gametes prior to conception, and that changes would be observed in offspring. The high rotenone concentration altered P0 growth, mitochondrial respiration, gene expression, induction of the mitochondrial unfolded protein response, and susceptibility to secondary challenge-induced dopaminergic neurodegeneration. However, we observed minor or no P0 effects at the low concentration. The F1 progeny of both low and high concentrations showed few effects, with most occurring in the high-exposure offspring. The only effects observed in the F1 offspring of the low exposure were a 1.7% decrease in egg size (but size later in development was not different from offspring of controls), and a slightly increased sensitivity to dopaminergic neurodegeneration caused by a secondary rotenone exposure. This study is a follow-up of Mello et. al. 2022 (PMID: 35273616; GEO: GSE195584)

2025-03-20 | GSE292176 | GEO

Effects of preconception exposure to rotenone on progeny depend on the degree of maternal toxicity

Project description:Effects of preconception exposure to rotenone on progeny depend on the degree of maternal toxicity

| PRJNA1237332 | ENA

Transcriptional response to rotenone exposure in C. elegans and the effects on progeny

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-03-20 | GSE292477 | GEO

Sequencing of Caenorhabditis elegans at two different time points after Rotenone and DMSO treatment (mRNA)

Project description:Comparison of gene expression profiles from C. elegans of Rotenone and Dimethylsulfoxid (DMSO) treated animals. The RNA-seq data comprise two age groups (5 and 15 days) and two different conditions (rotenone, DMSO). Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE110843 | GEO

Sequencing of Caenorhabditis elegans at two different time points after Rotenone and DMSO treatment (smallRNA)

Project description:Comparison of small RNA expression profiles from C. elegans of Rotenone and Dimethylsulfoxid (DMSO) treated animals. The RNA-seq data comprise two age groups (5 and 15 days) and two different conditions (rotenone, DMSO). Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

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Sequencing of Caenorhabditis elegans at 4 different time points after Rotenone and DMSO treatment (small RNA)

Project description:Comparison of small RNA expression profiles from C. elegans after Rotenone and Dimethylsulfoxid (DMSO) treatment. The RNA-seq data comprise 4 age groups (1, 5, 10 and 20 days) and two different treatments (Rotenone and DMSO). Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE110848 | GEO

Sequencing of Caenorhabditis elegans at 5 different time point after Rotenone and DMSO treatment (mRNA)

Project description:Comparison of gene expression profiles from C. elegans at different time points after Rotenone and Dimethylsulfoxid (DMSO) treatment. The RNA-seq data comprise 5 time points (6 hours, 1, 2, 3 and 5 days) treated with Rotenone and DMSO as well as 2 time points (3 and 5 days) with an additional H2O treatment. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE110834 | GEO

Sequencing of Caenorhabditis elegans at 5 different time point after Rotenone and DMSO treatment (smallRNA)

Project description:Comparison of small RNA expression profiles from C. elegans at different time points after Rotenone and Dimethylsulfoxid (DMSO) treatment. The RNA-seq data comprise 5 time points (6 hours, 1, 2, 3 and 5 days) treated with Rotenone and DMSO as well as 2 time points (3 and 5 days) with an additional H2O treatment. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

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mRNA-seq of wild-type C. elegans exposed to rotenone

Project description:To investigate the role of mitochondrial disruption on modulating conserved immunometabolic molecular pathways, we performed a whole transcriptome paired-end mRNA-seq analysis on C. elegans worms exposed to 0.5µM rotenone (a Complex I inhibitor) , or vehicle (0.125% dimethyl sulfoxide) . These results revealed 179 differentially expressed genes (134 up, 45 down) enriched for terms such as detoxification, energy metabolism, or pathogen defense. Whole transcriptome data revealed an association with the UPRmt and HIF-1 regulatory pathways.

2022-01-31 | GSE195584 | GEO

Deep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of rotenone at 4 different time points

Project description:Background: We here show that inhibitors of mitochondrial complex I promote physical activity, stress resistance as well as lifespan of Caenorhabditis elegans despite normal food uptake, i.e. in the absence of DR. Dietary restriction (DR) extends lifespan and promotes metabolic health in evolutionary distinct species. The RNA-seq data comprises 4 age groups (1, 5, 10 and 20 days after L4) and 2 different conditions (rotenone and normal feeding (DMSO)) 22 samples: mRNA profiles of 1-day, 5-day and 10-day old worms as triplicates for each, rotenone and solvent control treatment; mRNA profiles of 20-day old worms as duplicates for each, rotenone and solvent control treatment

2013-04-16 | E-GEOD-46051 | biostudies-arrayexpress

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