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Uncovering gene regulatory differences between human and chimpanzee neural cells [CUT&Tag]

ABSTRACT: Uncovering gene regulatory differences between human and chimpanzee neural cells [CUT&Tag]

PROVIDER: PRJNA1239914 | ENA |

REPOSITORIES: ENA

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Uncovering gene regulatory differences between human and chimpanzee neural cells [CUT&Tag]

Project description:A major challenge in human evolutionary biology is to pinpoint the genetic differences that underlie phenotypic changes in the human lineage, such as increased neuron number and a prolonged period of neuronal maturation. Here, we used human-chimpanzee tetraploid cells to distinguish changes in gene expression due to cis-acting sequence variants that change local gene regulation, from trans expression changes due to species differences in the cellular environment, in neural progenitor cells and excitatory neurons. Using a CRISPR inhibition screen, transcription factor motif analyses, and downstream single-locus studies, we further characterized cis-acting gene regulatory differences, including changes to FOS, TNIK, FOSL2, and MAZ, that influence neurogenesis and neuronal maturation. This study identifies specific genomic changes that may contribute to human neural specializations and provides a general framework for understanding genetic differences that underlie human traits.

2025-08-12 | GSE292529 | GEO

Uncovering gene regulatory differences between human and chimpanzee neural cells

Project description:Uncovering gene regulatory differences between human and chimpanzee neural cells

| PRJNA1263046 | ENA

Uncovering gene regulatory differences between human and chimpanzee neural cells

Project description:Uncovering gene regulatory differences between human and chimpanzee neural cells

| PRJNA1263045 | ENA

Uncovering gene regulatory differences between human and chimpanzee neural cells [scRNA-seq]

Project description:Uncovering gene regulatory differences between human and chimpanzee neural cells [scRNA-seq]

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Uncovering gene regulatory differences between human and chimpanzee neural cells [ATAC-seq]

Project description:Uncovering gene regulatory differences between human and chimpanzee neural cells [ATAC-seq]

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Uncovering gene regulatory differences between human and chimpanzee neural cells [RNA-seq]

Project description:Uncovering gene regulatory differences between human and chimpanzee neural cells [RNA-seq]

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CUT&TAG of OE19 cell line

Project description:To map the chromatin binding sites for SMC1 in OE19 cells, we performed CUT&TAG.

2024-09-25 | E-MTAB-14090 | biostudies-arrayexpress

CUT&TAG of OE19 cell line

Project description:To map the chromatin binding sites for various factors in OE19 cells, we performed CUT&TAG.

2023-02-24 | E-MTAB-11356 | biostudies-arrayexpress

Uncovering gene regulatory differences between human and chimpanzee neural cells [scRNA-seq]

2025-08-12 | GSE292632 | GEO

Uncovering gene regulatory differences between human and chimpanzee neural cells [RNA-seq]

2025-08-12 | GSE292688 | GEO

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