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Human Virome

ABSTRACT: Metagenomic Sequencing Samples of Throat Swabs from 72 Patients with Unexplained Fever

PROVIDER: PRJNA1240020 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32994100_1.fastq.gz	Fastqsanger.gz
	SRR32994100_2.fastq.gz	Fastqsanger.gz
	SRR32994101_1.fastq.gz	Fastqsanger.gz
	SRR32994101_2.fastq.gz	Fastqsanger.gz
	SRR32994102_1.fastq.gz	Fastqsanger.gz

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Human Virome

Project description:Metagenomic Sequencing Samples of Throat Swabs from 64 Patients with Unexplained Fever

| PRJNA1240019 | ENA

Human Virome

Project description:Metagenomic Sequencing Samples of Throat Swabs from 81 Influenza-Like Illness Patients

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Project description:Metagenomic Virome Study of Sputum Samples from 291 Children with Pneumonia

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Project description:Metagenomic Virome Study of Cerebrospinal Fluid Samples from 152 Children with Encephalitis

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Transcription profiling of S. aureus to investigate an outbreak of severe infections with community-acquired methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin following immunization - duplicate of E-BUGS-45

Project description:BACKGROUND: Infections with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are emerging worldwide. We investigated an outbreak of severe CA-MRSA infections in children following out-patient vaccination. METHODS AND FINDINGS: We carried out a field investigation after adverse events following immunization (AEFI) were reported. We reviewed the clinical data from all cases. S. aureus recovered from skin infections and from nasal and throat swabs were analyzed by pulse-field gel electrophoresis, multi locus sequence typing, PCR and microarray. In May 2006, nine children presented with AEFI, ranging from fatal toxic shock syndrome, necrotizing soft tissue infection, purulent abscesses, to fever with rash. All had received a vaccination injection in different health centres in one District of Ho Chi Minh City. Eight children had been vaccinated by the same health care worker (HCW). Deficiencies in vaccine quality, storage practices, or preparation and delivery were not found. Infection control practices were insufficient. CA-MRSA was cultured in four children and from nasal and throat swabs from the HCW. Strains from children and HCW were indistinguishable. All carried the Panton-Valentine leukocidine (PVL), the staphylococcal enterotoxin B gene, the gene complex for staphylococcal-cassette-chromosome mec type V, and were sequence type 59. Strain HCM3A is epidemiologically unrelated to a strain of ST59 prevalent in the USA, although they belong to the same lineage. CONCLUSIONS: We describe an outbreak of infections with CA-MRSA in children, transmitted by an asymptomatic colonized HCW during immunization injection. Consistent adherence to injection practice guidelines is needed to prevent CA-MRSA transmission in both in- and outpatient settings. Data is also available from http://bugs.sgul.ac.uk/E-BUGS-45

2009-01-16 | E-BUGS-45 | biostudies-arrayexpress

Human Virome

Project description:Viromics Study of Serum Samples from 214 Febrile Patients, Pooled into 54 Pools

| PRJNA1240014 | ENA

Project description:metagenomic sequencing on throat and rectal swabs from Rucervus eldii

| PRJNA1138552 | ENA

Human Virome

Project description:Viromics Study of 421 Serum Samples (Single Samples, Non-Pooled)

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Insights into myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) phenotypes through comprehensive metabolomics (part II)

Project description:The pathogenesis of ME/CFS, a disease characterized by unexplained debilitating fatigue, cognitive dysfunction, sleep disturbances, orthostatic intolerance, fever, lymphadenopathy and irritable bowel syndrome (IBS), is poorly understood. There are no validated diagnostic tests or interventions to mitigate disease. Here we report association modeling, biomarker discovery, biochemical enrichment analysis and topological network visualization of plasma metabolomic, fecal bacterial metagenomic and clinical data from 50 ME/CFS patients and 50 healthy controls.

2017-07-19 | ST000801 | MetabolomicsWorkbench

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