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Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation_Male cerebrum study

ABSTRACT: Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation_Male cerebrum study

PROVIDER: PRJNA1240361 | ENA |

REPOSITORIES: ENA

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Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation_Female cerebrum study

Project description:Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation_Female cerebrum study

| PRJNA1240354 | ENA

Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation_Male cerebrum study

Project description:This study investigates the impact of central nervous system sulfatide (ST) deficiency on gene expression in the male mouse cerebrum tissues, both in the presence and absence of Trem2, using the NanoString Neuroinflammation panel.

2025-09-04 | GSE292643 | GEO

Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation_Female cerebrum study

Project description:This study investigates the impact of central nervous system sulfatide (ST) deficiency on gene expression in the female mouse cerebrum tissues, both in the presence and absence of Trem2, using the NanoString Neuroinflammation panel.

2025-09-04 | GSE292640 | GEO

Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation_Female spinal cord study

Project description:Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation_Female spinal cord study

| PRJNA1240358 | ENA

Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation_Female spinal cord study

Project description:This study investigates the impact of central nervous system sulfatide (ST) deficiency on gene expression in the female mouse spinal cord tissues, both in the presence and absence of Trem2, using the NanoString Neuroinflammation panel.

2025-09-04 | GSE292641 | GEO

Danionella cerebrum

Project description:Danionella cerebrum overview

| PRJNA1087479 | ENA

The lncRNA expression profiles in hepatocellular carcinoma cell lines under sulfatide treatment

Project description:Sulfatide significantly promoted hepatocellular carcinoma cells survival, proliferation and angiogenesis. To understand the molecular mechanisms of sulfatide, the transcriptional profiles of lncRNAs in human hepatocellular carcinoma cells SMMC-7721 was investigated with ArrayStar lncRNA microarray with sulfatide treatment. Galactose-cerebroside treatment served as the control.

2020-05-25 | GSE151111 | GEO

Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination

Project description:Myelination of axons enables efficient signal propagation in neurones. Myelin is a multi-layered membrane that wraps around neuronal axons forming extremely tight contacts that insulate the axon. Tight contact between the axon and myelin sheath is mediated by specific plasma membrane proteins and lipids, with disruption to these contacts causing devastating demyelinating diseases. We have generated two cell-based models of demyelinating sphingolipidoses and shown that the altered lipid metabolism changes the plasma membrane protein composition. The proteins that are altered in these cells play roles in cell adhesion and signalling, several of which have previously been implicated in a range of neurological diseases. The adhesion molecule Neurofascin, with a known role in myelin-axon contact sites, is significantly altered in response to sphingolipid imbalances, highlighting a potential new player contributing to the pathogenesis of galactosphingolipid-mediated diseases. We show that the Neurofascin isoform NF155, but not NF186, directly binds the sphingolipid sulfatide, but does not bind other galactosylated-sphingolipids. Furthermore, this interaction requires the full-length extracellular domain of NF155 and that the structure of this domain adopts an S-shape with important implications for the arrangement of proteins in the tight axon-myelin space. Together, this work identifies that glycosphingolipid imbalances drive changes in membrane protein abundance and that this may be driven by direct interactions between extracellular portions of these proteins with specific lipid headgroups.

2023-04-06 | PXD036727 | Pride

Expression quantitative trait locus analysis of chicken cerebrum

Project description:This data originates from an expression quantitative trait locus analysis of cerebrum in an advanced intercross of Red Jungefowl and White Leghorn chickens. The aim of the study was to map the genetic basis of cerebrum and body mass, and idenifiy transcriptional differences within the intercross to assess any candidate genes for cerebrum and body mass.

2020-07-07 | E-MTAB-9313 | biostudies-arrayexpress

Transcription profiling of human fetal cerebellum, heart, cerebrum, and cerebrum derived astrocyte cell line from trisomy 21 and trisomy 13 samples

Project description:Gene expression was measured in trisomy 21 and trisomy 13 human fetal samples. For TS21, regions assayed were cerebrum, cerebellum, heart, and cerebrum-derived astrocyte cell lines.

2008-06-11 | E-GEOD-1397 | biostudies-arrayexpress

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