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Differential Expression and Correlation Analysis of Global Transcriptome for Obstructive Sleep Apnea Hypopnea Syndrome

ABSTRACT: Differential Expression and Correlation Analysis of Global Transcriptome for Obstructive Sleep Apnea Hypopnea Syndrome

PROVIDER: PRJNA1244422 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32926706_1.fastq.gz	Fastqsanger.gz
	SRR32926706_2.fastq.gz	Fastqsanger.gz
	SRR32926707_1.fastq.gz	Fastqsanger.gz
	SRR32926707_2.fastq.gz	Fastqsanger.gz
	SRR32926708_1.fastq.gz	Fastqsanger.gz

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Differential Expression and Correlation Analysis of Global Transcriptome for Obstructive Sleep Apnea Hypopnea Syndrome

Project description:In order to investigate the gene expression patterns and molecular regulatory mechanisms of obstructive sleep apnea hypopnea syndrome (OSAHS), the global transcriptome expression profiles of OSAHS patients and healthy people were analyzed using transcriptome sequencing technology. Differential expression of circular RNA, microRNA, long noncoding RNA, and messenger RNA was investigated between the two groups.

2025-04-01 | GSE293433 | GEO

Epigenome analysis of peripheral blood mononuclear cell (PBMC) samples from obstructive sleep apnea patients and healthy subjects

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Project description:Obstructive Sleep Apnea is a sleep-related breathing disorder. Differential methylation analysis was conducted to evaluate differentially methylated regions across the chromosomes in patients with severe OSA compared to healthy subjects. We further evaluated how these differentially methylated regions were altered with long-term (24 months) continuous positive airway pressure treatment.

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Transcriptome analysis of adult patients with severe Obstructive Sleep Apnea before and after CPAP treatment.

Project description:Obstructive Sleep Apnea, a sleep related breathing disorder RNA sequencing analysis was conducted to evaluate differentially expressed genes in patients with severe OSA compared to healthy subjects. We further evaluated how these differentially expressed genes and associated pathways altered with short-term (4 months) vs. long-term (24 months) continuous positive airway pressure treatment.

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Serum proteomic analysis by tandem mass tags-based quantitative proteomics in pediatric obstructive sleep apnea

Project description:Pediatric obstructive sleep apnea (OSA) is a frequent respiratory disorder with an estimated prevalence of 3–6% in the general population. However, the underlying pathophysiology of OSA remains unclear. Recently, proteomic analysis using high-resolution and high-throughput mass spectrometry has been widely used in the field of medical sciences. In the present study, tandem mass tags (TMT)-based proteomic analysis was performed in the serum of patients with OSA.

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Visceral fat trancriptome in obstructive sleep apnea

Project description:Rationale: Obstructive sleep apnea (OSA) has been associated with metabolic dysregulation and systemic inflammation. This may be due to pathophysiologic effects of OSA on visceral adipose tissue. We sought to assess the transcriptional consequences of OSA on adipocytes by utilizing pathway-focused analyses. Methods: Patients scheduled to undergo ventral hernia repair surgery were recruited to wear a portable home sleep monitor for two nights prior to surgery. Visceral fat biopsies were obtained intra-operatively. RNA was extracted and whole-genome expression profiling was performed. Gene Set Enrichment Analysis (GSEA) was used to identify curated gene sets that were differentially enriched in OSA subjects. Network analysis was applied to a select set of highly enriched pathways. Results: 10 patients with OSA and 8 control subjects were recruited. There were no differences in age, gender, body mass index between the two groups, but the OSA subjects had a significantly higher respiratory disturbance index (19.2 vs. 0.6, P-value 0.05) and worse hypoxemia (minimum oxygen saturation 79.7% vs. 87.8%, P-value < 0.001). GSEA identified a number of gene sets up-regulated in adipose tissue of OSA patients including the pro-inflammatory NF-M-NM-:B pathway and the proteolytic ubiquitin/proteasome module. A critical metabolic pathway, the peroxisome proliferator-activated receptor (PPAR), was down-regulated in subjects with OSA. Network analysis linked members of these modules together and identified regulatory hubs. Conclusions: OSA is associated with alterations in visceral fat gene expression. Pathway-based network analysis highlighted perturbations in several key pathways whose coordinated interactions may contribute to the metabolic dysregulation observed in this complex disorder. Total RNA from visceral fat of 18 subjects (10 OSA, 8 Control) was hybridized to 18 Affymetrix Genechip Human Gene 1.0 ST microarrays.

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Project description:To understand the molecular change occurring in the atria during obstructive sleep apnea, we have implemented a rat model of OSA involving the surgical implantation of a tracheal obstructive device, allowing the rats to remain conscious and free-roaming throughout 2 weeks of apnea administration. Rats were divided into severe and moderate apnea groups, receiving a 23 second or 13 second apneas per minute, respectively. The two-dimensional polyacrylamide gel electrophoresis (2D PAGE) of atrial homogenates to compare the dysregulations in the protein pattern in severe and moderate apnea when compared to control.

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