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ERG-driven gene expression in basal and luminal cells of mouse prostate organoids

ABSTRACT: ERG-driven gene expression in basal and luminal cells of mouse prostate organoids

PROVIDER: PRJNA1247788 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR33016119_1.fastq.gz	Fastqsanger.gz
	SRR33016119_2.fastq.gz	Fastqsanger.gz
	SRR33016120_1.fastq.gz	Fastqsanger.gz
	SRR33016120_2.fastq.gz	Fastqsanger.gz
	SRR33016121_1.fastq.gz	Fastqsanger.gz

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ERG-driven gene expression in basal and luminal cells of mouse prostate organoids

Project description:ETS transcription factor ERG is aberrantly activated in ~50% of human prostate cancers. We found that ERG shows a preference of basal over luminal context to drive prostate cancer. However, the molecular basis of the cell context dependency remains elusive. Here we use ERG+/+;Pten-/- (EP) mouse prostate organoids with dual basal/luminal lineage reporters to profile ERG-driven gene expression programs from sorted basal vs luminal cells.

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