Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Replicative and irradiation-induced senescence of endothelial cells

ABSTRACT: Replicative and irradiation-induced senescence of endothelial cells

PROVIDER: PRJNA1251521 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR33156103.fastq.gz	Fastqsanger.gz
	SRR33156104.fastq.gz	Fastqsanger.gz
	SRR33156097.fastq.gz	Fastqsanger.gz
	SRR33156098.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Replicative and irradiation-induced senescence of endothelial cells

Project description:This research investigates cellular senescence in human umbilical vein endothelial cells (HUVECs), focusing on their implications for cardiovascular diseases. We employed RNA sequencing to analyze gene expression changes in HUVECs subjected to replicative- or stress-induced senescence via ionizing radiation. Our findings reveal that both senescence types exhibit significant upregulation of genes associated with epithelial-mesenchymal transition (EMT) and inflammatory pathways, indicating a shared molecular response. Experimental validation confirmed reduced proliferation and increased secretion of pro-inflammatory cytokines (IL-6 and IL-8) in senescent cells and substantiated the upregulation of EMT marker genes. Additionally, we observed impaired wound healing capacity in senescent cells, highlighting the functional consequences of these cellular state. Our study underscores the critical role of senescence-related changes, contributing to the understanding of age-related cardiovascular pathologies.

2025-06-18 | GSE294733 | GEO

Microarray analysis of Replicative senescence and TNF-α induced senescence in Human umbilical vein endothelial cells (HUVECs)

Project description:Cellular senescence is a dynamic tumor suppression mechanism that limits the proliferation of impaired cells, by executing a stable cell cycle arrest. Understanding the molecular pathways and regulatory circuits that are involved in the process of senescence is presently incomplete. In this study, we determined the changes in gene expression during the establishment of replicative senescence, by comparing the expression profiles of young and senescent human umbilical vein endothelial cells (HUVECs). Exploration of array data using ingenuity pathway analysis showed that genes involved in cell cycle regulation, cellular assembly and organization, DNA replication, recombination and repair were significantly down regulated during senescence.

2022-01-27 | GSE195517 | GEO

Microarray analysis of Replicative senescence and TNF-α induced senescence in Human umbilical vein endothelial cells (HUVECs)

Project description:Microarray analysis of Replicative senescence and TNF-α induced senescence in Human umbilical vein endothelial cells (HUVECs)

| PRJNA801004 | ENA

Analysis of the senescence transcriptome in TRF2dBdM-induced senescence and replicative senescence [microarray]

Project description:Analysis of the senescence transcriptome in TRF2dBdM-induced senescence and replicative senescence [microarray]

| PRJNA644554 | ENA

Transcriptome analysis of IMR-90 human fibroblasts following oncogene-induced and replicative senescence

Project description:By transcriptome analysis of IMR-90 human fibroblasts following oncogene-induced senescence (OIS) and replicative senescence (RS), we identified commonly regulated genes in both conditions.

2017-03-30 | GSE86546 | GEO

MicroRNA signature of young and replicative senescent human umbilical vein endothelial cells (HUVECs)

Project description:MicroRNAs regulate various cellular processes. While several genes associated with replicative senescence have been described in endothelial cells, miRNAs that regulate these genes remain largely unknown. The present study was designed to identify miRNAs associated with replicative senescence and their target genes in HUVECs. We have employed Agilent Human MicroRNAs microarray platform to evaluate the expressions of 866 human miRNAs and 89 human viral miRNAs, based on Sanger miRNA database release 12.0 miRNA expression profiles were established for young and replicative senescent HUVECs

2013-04-05 | E-GEOD-37092 | biostudies-arrayexpress

Gene signature of young and replicative senescent human umbilical vein endothelial cells (HUVECs)

Project description:MicroRNAs regulate various cellular processes. While several genes associated with replicative senescence have been described in endothelial cells, miRNAs that regulate these genes remain largely unknown. The present study was designed to identify miRNAs associated with replicative senescence and their target genes in HUVECs. Gene profiling was established using the same RNA input as that used for miRNA profiing. We have employed Agilent Whole Human Genome microarray platform to evaluate the expressions of 19,596 human genes . Gene expression profiles were established for young and replicative senescent HUVECs

2013-04-05 | E-GEOD-37091 | biostudies-arrayexpress

Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance

Project description:Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance

| PRJNA801491 | ENA

RNAseq of Normal Human Epidermal Keratinocytes (NHEKs) in UVB-induced senescence (UVB-SIPS, at 3 days or 5 days) or in replicative-like senescence (RS)

Project description:RNAseq analyses of NHEKs in replicative-like senescence, i.e. in growth arrest after about ten passages in culture, or in premature senescence induced by repeated UVB exposures (UVB-SIPS), at 3 days and at 5 days after the last UVB stress.

2022-12-31 | E-MTAB-10969 | biostudies-arrayexpress

Analysis of the senescence transcriptome in TRF2dBdM-induced senescence and replicative senescence [microarray]

Project description:We stably infected IMR90 fibroblasts with lentiviral vectors expressing doxycycline-inducible TRF2dBdM or vector control. Cells were treated with 1mg/ml of doxycycline for 7 days to induce senescence in the cells expressing TRF2dBdM before collecting RNA. IMR90 cells, either young (passage 10, population doubling ~20) or old (passage 24, population doubling ~40-48) were also used as a model of replicative senescence. The transcriptomes were analyzed using RNA microarrays.

2021-02-12 | GSE153922 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data