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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [Xenium]

ABSTRACT: Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [Xenium]

PROVIDER: PRJNA1252739 | ENA |

REPOSITORIES: ENA

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Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [Xenium]

Project description:To investigate the role UTX (KDM6A) in stratifying epithelia

2025-06-04 | GSE295061 | GEO

Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [CUT&RUN]

Project description:Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [CUT&RUN]

| PRJNA1251688 | ENA

Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [ChIP-seq]

Project description:Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [ChIP-seq]

| PRJNA1251689 | ENA

Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [RNA-seq]

Project description:Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [RNA-seq]

| PRJNA1252736 | ENA

Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [RNA-seq]

Project description:To investigate the role UTX (KDM6A) in stratifying epithelia

2025-05-22 | GSE295058 | GEO

Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [ChIP-seq]

Project description:To investigate the role UTX (KDM6A) in stratifying epithelia

2025-05-22 | GSE294851 | GEO

Utx (Kdm6a) promotes differentiation non-catalytically in somatic self-renewing epithelia [CUT&RUN]

Project description:To investigate the role UTX (KDM6A) in stratifying epithelia

2025-05-22 | GSE294850 | GEO

Alternative mRNA splicing controls functions of the human H3K27 demethylase UTX/KDM6A

Project description:The UTX/KDM6A gene encodes the UTX histone H3K27 demethylase, which plays an important role in mammalian development and is frequently mutated in cancers and particularly, in urothelial cancers. Using BioID technique, we explored the interactome of different UTX isoforms.

2024-01-28 | PXD041254 | Pride

KDM6A(UTX) is an epigenetic gatekeeper of mTORC1 signalling in cancer

Project description:Large-scale genome sequencing efforts of human tumors identified epigenetic modifiers as one of the most frequently mutated gene class in human cancer. However, how these mutations drive tumor development and progression is largely unknown. Here, we identify the histone demethylase KDM6A as an important tumor suppressor in solid cancers, such as liver cancer and pancreatic cancer. KDM6A-deficient tumors show hyperactivation of mTORC1 signaling, whereas endogenous KDM6A re-expression in established KDM6A-deficient tumors diminishes mTORC1 activity by fostering the expression of crucial negative pathway regulators, such as DEPTOR, TSC1, and TSC2, resulting in tumor regression. Importantly, KDM6A expression in human tumors correlates with mTORC1 activity and KDM6A-deficient tumors exhibit increased sensitivity to mTORC1 inhibition. Hence, our results link KDM6A-dependent epigenetic remodeling to mTORC1 signaling and provide a potential therapeutic strategy for KDM6A-deficient tumors.

2022-07-20 | GSE155630 | GEO

KDM6A/UTX promotes spermatogenic gene expression across generations but is dispensable for male fertility

Project description:Paternal chromatin undergoes extensive structural and epigenetic changes during mammalian spermatogenesis, producing sperm with an epigenome optimized for the transition to embryogenesis. Lysine demethylase 6a (KDM6A, also called UTX) promotes gene activation in part via demethylation of H3K27me3, a developmentally important repressive modification abundant throughout the epigenome of spermatogenic cells and sperm. We previously demonstrated increased cancer risk in genetically wild type mice derived from a paternal germ line lacking Kdm6a (Kdm6a cKO), indicating a role for KDM6A in regulating heritable epigenetic states. However, the regulatory function of KDM6A during spermatogenesis is not known. Here, we show that Kdm6a is transiently expressed in spermatogenesis, with RNA and protein expression largely limited to late spermatogonia and early meiotic prophase. Kdm6a cKO males do not have defects in fertility or the overall progression of spermatogenesis. However, hundreds of genes are deregulated upon loss of Kdm6a in spermatogenic cells, with a strong bias towards downregulation coinciding with the time when Kdm6a is expressed. Misregulated genes encode factors involved in chromatin organization and regulation of repetitive elements, and a subset of these genes was persistently deregulated in the male germ line across two generations of offspring of Kdm6a cKO males. Genome-wide epigenetic profiling revealed broadening of H3K27me3 peaks in differentiating spermatogonia of Kdm6a cKO mice, suggesting that KDM6A demarcates H3K27me3 domains in the male germ line. Our findings highlight KDM6A as a transcriptional activator in the mammalian male germ line that is dispensable for spermatogenesis but important for safeguarding gene regulatory state intergenerationally.

2023-10-24 | GSE215112 | GEO

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