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Transcriptomic response of ethanol extract of Jakyakgamcho-tang (JGT-E) in C2C12 myotube

ABSTRACT: Transcriptomic response of ethanol extract of Jakyakgamcho-tang (JGT-E) in C2C12 myotube

PROVIDER: PRJNA1252750 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR33214331_1.fastq.gz	Fastqsanger.gz
	SRR33214331_2.fastq.gz	Fastqsanger.gz
	SRR33214338_1.fastq.gz	Fastqsanger.gz
	SRR33214338_2.fastq.gz	Fastqsanger.gz

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Transcriptomic response of ethanol extract of Jakyakgamcho-tang (JGT-E) in C2C12 myotube

Project description:Whole transcriptomic analysis in C2C12 myotube cells was conducted, comparing cells treated with a vehicle control to those treated with three different concentrations of JGT-E. All experiments were performed in triplicate.

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Jakyak-gamcho-tang ameliorates dexamethasone-induced muscle atrophy and muscle dysfunction [C2C12]

Project description:Jakyak-gamcho-tang (JGT) is a herbal medicine that has been traditionally prescrived for pain control including muscular pain. This transcriptome analysis aims to investigate the changes in global gene expression profile in differentiated murine C2C12 myotube cells treated with JGT extract.

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Large scale cell-based transcriptome data treated with Jakyakgamcho-tang in HepG2 cell

Project description:Jakyakgamcho-tang (JGT) is the simplest form of herbal medicine composed of Paeoniae Radix (PR) and Glycyrrhizae Radix at Rhizoma (GR), and has been used to treat muscle-related diseases and inflammation. However, the pharmacological effects of JGT may vary depending on the ratio of the constituent herbs and the main preparation conditions of the extraction method. Nevertheless, no gene expression dataset systematically reflecting these various variables has existed to date. In this study, a total of 498 transcriptome profiles were constructed with three concentrations and three replicates of RNA-seq data. It is structured to enable multidimensional analysis of the effects of various preparation conditions on gene expression by combining the ratio of PR:GR (2:1, 1:1, 1:2), solvent (water, 70% ethanol), and extraction method (combined decoction vs. separate decoction) of JGT, targeting three cell lines (HepG2, C2C12, and PC12). All raw and preprocessed data are deposited available through GEO, and standardized metadata and ingredient data are also provided. This dataset provides a foundation for exploring how traditional herbal medicine formulations affect cellular transcriptomic responses and can serve as a baseline for scientific optimization of herbal medicines.

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Transcriptomic response of ginsenoside Rc (gRc) in C2C12 myotube under H2O2-induced oxidative stress

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Project description:Neuropathic pain (NP) is a chronic condition caused by complex molecular mechanisms. Due to the challenges in NP treatment, it is crucial to develop novel targeting strategies that can help elucidate its molecular mechanisms. Jakyakgamcho-tang (JGT) has significant therapeutic potential; however, its precise mechanism of action remains unclear. In this study, we systematically investigated the key transcription factors and mechanisms of action of water/ethanol extract of JGT (WJGT/EJGT) and their compounds using transcriptome analysis. We identified key transcription factor involved in NP pathogenesis by profiling transcriptome and histone ChIP-seq from NP model. We analyzed gene expression changes in PC12 cells treated with JGT extract to determine its key mechanisms and transcriptional regulators. To further validation the novel mechanisms and targets of JGT and its key compounds, we conducted in vitro experiments. The PDGFRB pathway was significantly downregulated by JGT extracts, with Fos identified as a key transcription factor regulating JGT-induced target gene expression. Furthermore, we identified key compounds among seven compounds that were regulated by the PDGFRB pathway and Fos expression. Notably, the targets modulated by JGT extracts and its key compounds were associated with inflammation. Our findings suggest that targeting the PDGFRB pathway and its key transcription factor, Fos, is a potential therapeutic strategy for NP. This study provides novel insights into the mechanism and transcriptional regulator underlying JGT and its key compounds in NP treatment.

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