Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: 16S Porcupine Abyssal Plain

PROVIDER: PRJNA1252773 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR33218150_1.fastq.gz	Fastqsanger.gz
	SRR33218150_2.fastq.gz	Fastqsanger.gz
	SRR33218151_1.fastq.gz	Fastqsanger.gz
	SRR33218151_2.fastq.gz	Fastqsanger.gz
	SRR33218152_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

Project description:18S Porcupine Abyssal Plain

| PRJNA1252971 | ENA

marine metagenome

Project description:Porcupine Seabight 16S Ribosomal RNA

| PRJDA73021 | ENA

Project description:Hedgehog Spine and Porcupine Quill 16S Amplicons

| PRJNA720886 | ENA

Orchid tissue TMT Quantitative analysis

Project description:We collected samples of Pistil, Plain Valve, Plain lip and Plain calyx from the same period and quenched them in liquid nitrogen. Two biological replications were performed in each sample. TMT labeled quantitative proteomics was used to analyze different proteins in different tissues. GO and KEGG were used to analyze the differentially expressed proteins in different tissues, and the key proteins in the important pathway were found

2022-02-15 | PXD019636 | Pride

marine sediment metagenome

Project description:Molecular ecological analyses for microbial communities associated with abyssal plain sediment of the Pacific Ocean

| PRJDB9793 | ENA

Project description:16S sequencing from Carrizo Plain NM soil samples

| PRJNA1201319 | ENA

Metagenomes from Gulf of Mexico deep-sea sediments

Project description:Metagenomes from deep sea sediments collected at the continental slope and abyssal plain in southern Gulf of Mexico

| PRJEB47540 | ENA

WNT ligands control initiation and progression of human papilloma-virus-driven squamous cell carcinoma

Project description:Human papilloma virus (HPV)-driven cutaneous squamous cell carcinoma (cSCC) is the most common cancer in immunosuppressed patients. Despite indications suggesting that HPV promotes genomic instability during cSCC development, the molecular pathways underpinning HPV-driven cSCC development remain unknown. We compared the transcriptome of HPV-driven mouse cSCC with normal skin and observed higher amounts of transcripts for Porcupine and WNT ligands in cSCC, suggesting a role for WNT-signaling in cSCC progression. We confirmed increased Porcupine expression in human cSCC samples. Blocking the secretion of WNT-ligands by the Porcupine inhibitor LGK974 significantly diminished initiation and progression of HPV-driven cSCC. Administration of LGK974 to mice with established cSCC resulted in differentiation of cancer cells and significant reduction of the cancer stem cell compartment. Thus, WNT/b-catenin signaling is essential for HPV-driven cSCC initiation and progression as well as for maintaining the cancer stem cell niche. Interference with WNT-secretion may thus represent a promising approach for therapeutic intervention.

2018-12-13 | GSE108454 | GEO

RNA-Seq identification of LGK974 early and late gene targets in AsPC-1

Project description:RNA sequencing with differential gene expression analysis was performed on AsPC-1 pancreatic ductal adenocarcinoma (PDAC) cells at multiple time points with a Porcupine inhibitor (LGK974) to identify mechanisms underpinning transcriptional effects.

2022-04-19 | GSE180615 | GEO

Analysis of Porcupine ablation within the uterine epithelium on gene expression within the uterus

Project description:The secretion of mammalian Wnt Ligands within the cell is dependent on the activity of Porcupine, a gene located on the X chromosome that encodes for a membrane bound o-acyl transferase. Porcupine-dependent Wnt signalling was previously shown to be essential for the post-natal maintenance of endometrial glands, structures that are essential for implantation and fertility. Previous data has implicated the multiple members of the Wnt family expressed in the female uterus to be involved in a coordinated crosstalk between the luminal and stromal compartments of the uterus, ensuring the proper development of the uterus and successful fertility. We have generated a conditional mutant of Porcupine in the luminal epithelium (cKOepi) of the uterus, thus eliminating Wnt7a/b and Wnt11, to address the nature of this crosstalk. Unlike global luminal-stromal mutants, post-natal ablation of Porcupine in the luminal epithelium alone does not affect the maintenance of the endometrial glands in adults. Uterine glands are still visible in the adult cKOepi, albeit in a smaller number than that of control uteri. Despite having uterine glands, cKOepi females remain completely infertile. We have attributed the sterility of these females to be in part due to defects in implantation and decidualization; cKOepi fail to respond to decidual induction by artificial means. Interestingly, progesterone supplementation rescues the observed implantation defects, although observed decidual soon seem to become resorptive. Microarray analysis of cKOepi during implantation has reveals several potential targets for luminal WNT that may be responsible for the observed phenotype including: Lef1, Hoxa10, Wnt4, Wnt16 Notch1, Notch4 and Dll4 .

2017-03-21 | GSE96801 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data