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Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors II

ABSTRACT: Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors II

PROVIDER: PRJNA1253619 | ENA |

REPOSITORIES: ENA

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Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors

Project description:Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors

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Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors

Project description:Committed progenitors with innate lymphoid cell (ILC) developmental potential are present in the fetus and bone marrow (BM). However, how fetal and BM hematopoiesis temporally and spatially contributes to ILC pools remains unclear. Here, we elucidated the distinct origins and developmental pathways of extramedullary and intramedullary ILCs during ontogeny. ILC-restricted hematopoiesis is initiated in the fetal liver (FL) and then FL-derived PD-1+ ILC progenitors (ILCPs) seed fetal lung and intestine. Organ niches determine the commitment of ILCPs to downstream precursors, including bipotent ILC1-ILC3 precursors (ILC1/3Ps) that are preferentially residing in the liver and intestine and ILC2 precursors (ILC2Ps) that show predominance in the lung. These precursors persist in adulthood and contribute to local ILC pools via BM-independent manner. In contrast, intramedullary ILC2Ps and ILC2s rely on BM hematopoiesis. Thus, our study highlights extramedullary and intramedullary ILCs with different origins, providing a comprehensive framework for developmental dynamics of ILCs.

2025-07-14 | GSE294130 | GEO

Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors II

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RNA-seq of mouse common lymphoid progenitors, innate lymphoid cell progenitors and NK cell progenitors

Project description:Natural Killer (NK) cells at different developmental stages (common lymphoid progenitor (CLP), innate lymphoid cell progenitors (ILCP), and refined NK progenitor (NKP)) were collected from Vav1+iCre FOXO1,3flox/flox mice (C57BL/6 background). Total RNA was harvested and sequenced with a strand-specific paired-end RNA-seq protocol.

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Skin-resident innate lymphoid cells converge on a pathogenic effector state

Project description:Skin-resident innate lymphoid cells converge on a pathogenic effector state

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The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors [DNase-seq]

Project description:Helper innate lymphoid cells (ILC) play important functions in immunity and tissue homeostasis, but their development remains poorly understood. In this study, we identified NFIL3 as the earliest known requirement during ILC development. Forced expression of NFIL3 in mouse lymphoid progenitors in vitro triggered the staged expression of downstream transcription factors including Tcf7, Gata3, Zbtb16 and Id2 that are implicated in ILC development. Thus, NFIL3 resides at the apex of a hierarchy of transcription factors important for innate lymphocyte development, and is necessary and sufficient to impose the innate lymphoid cell fate.

2025-10-30 | GSE291319 | GEO

The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors [CUT&RUN]

2025-10-30 | GSE291321 | GEO

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RNA-seq of mouse common lymphoid progenitors, innate lymphoid cell progenitors and NK cell progenitors

Project description:RNA-seq of mouse common lymphoid progenitors, innate lymphoid cell progenitors and NK cell progenitors

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The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors [RNA-seq - Tox]

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