Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Vaccination against Onchocerca volvulus induces IgG-mediated protective immunity dependent on neutrophils and complement

ABSTRACT: Vaccination against Onchocerca volvulus induces IgG-mediated protective immunity dependent on neutrophils and complement

PROVIDER: PRJNA1256276 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Vaccination against Onchocerca volvulus induces IgG-mediated protective immunity dependent on neutrophils and complement

Project description:Onchocerciasis remains a significant cause of morbidity and economic loss in sub-Saharan Africa. Despite the existence of effective therapeutics, a prophylactic vaccine targeting the etiologic agent, Onchocerca volvulus, is needed to control ongoing disease and transmission. Mice were vaccinated against O. volvulus with a fusion of the recombinant antigens Ov-103 and Ov-RAL-2 (Ov-FUS-1) with Advax-CpG adjuvant. Immunized mice developed protective immunity with the killing of third-stage larvae (L3) within 36 hours of challenge infection. IgG from immunized mice passively transferred protective immunity to naïve mice, indicating that antigen-specific IgG mediated parasite elimination. Neutrophils were the most abundant subset of immune cells recruited to the parasite microenvironment in vivo, and their depletion resulted in the total loss of immune-mediated larval killing. Analysis of neutrophil gene expression revealed that both vaccination and the presence of O. volvulus larvae were capable of modulating neutrophil transcriptional activity. The mechanism by which antigen-specific IgG and neutrophils collaborated to kill L3 was independent of Fcγ receptors. However, the elimination of complement component C3 prevented vaccine-induced protection, which suggests these components may interact through the complement system. This study describes a vaccine-induced mechanism of protective immunity against O. volvulus L3 dependent on IgG, neutrophils, and complement, highlighting an effective collaboration between the innate and adaptive arms of the immune system to control O. volvulus infection.

2025-09-10 | GSE295728 | GEO

Onchocerca volvulus transcriptomics

Project description:This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/ Onchocerca volvulus is a filarial nematode parasite of humans, causing Onchocerciasis, or River Blindness, which affects over 37 million people, mainly in Africa. It is a severely debilitating disease, which is transmitted to humans by black fly. This project aims to undertake high-throughput sequencing of Onchocerca volvulus transcriptome for de novo assembly of transcripts. The main objective of this project is to recognize genes expressed in given life stages.

2013-01-28 | E-ERAD-67 | biostudies-arrayexpress

Onchocerca volvulus

Project description:Onchocerca volvulus Genome sequencing

| PRJNA219638 | ENA

Onchocerca volvulus

Project description:Variation in Onchocerca volvulus

| PRJNA289926 | ENA

Onchocerca volvulus

Project description:Onchocerca volvulus poolSeq from 20 female worms from Ecuador

| PRJNA336187 | ENA

Onchocerca volvulus strain:NA

Project description:Onchocerca volvulus genome sequencing project

| PRJNA37761 | ENA

Onchocerca-derived small RNAs in host nodules and serum

Project description:We report the presence of Onchocerca ochengi and O. volvulus derived small RNAs in bovine nodule fluids and human serum and plasma, respectively. Further comparisons with other related filarial nematodes like Litomosoides sigmodontis and Dirofilaria immitis reveal common and distictive signatures associated to the Onchocerca species.

2015-04-24 | GSE63933 | GEO

Viral metagenomics of Onchocerca volvulus

Project description:Viral metagenomics of Onchocerca volvulus

| PRJEB67302 | ENA

Wolbachia endosymbiont of Onchocerca volvulus

Project description:Wolbachia endosymbiont of Onchocerca volvulus Genome sequencing

| PRJNA43537 | ENA

Wolbachia endosymbiont of Onchocerca volvulus

Project description:Endosymbiont of Onchocerca volvulus, the microfilarium causing river blindness.

| PRJNA12625 | ENA