Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

ABSTRACT: Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

PROVIDER: PRJNA1260402 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR33473400_1.fastq.gz	Fastqsanger.gz
	SRR33473400_2.fastq.gz	Fastqsanger.gz
	SRR33473401_1.fastq.gz	Fastqsanger.gz
	SRR33473401_2.fastq.gz	Fastqsanger.gz
	SRR33473402_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

Project description:Monocytes are a critical innate immune system cell type that serves homeostatic and immunoregulatory functions. They have been identified historically by the cell surface expression of CD14 and CD16. However, recent single-cell studies have revealed that they are much more heterogeneous than previously realized. We utilized cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) and single-cell RNA sequencing (scRNA-seq) to describe the comprehensive transcriptional and phenotypic landscape of 437,126 monocytes. This high-dimensional multimodal approach identified vast phenotypic diversity and functionally distinct subsets, including IFN-responsive, MHCIIhi, monocyte-platelet aggregates, as well as non-classical, sand several subpopulations of classical monocytes. Using flow cytometry, we validated the existence of MHCII+CD275+ MHCIIhi, CD42b+ monocyte-platelet aggregates, CD16+CD99- non-classical monocytes, and CD99+ classical monocytes. Each subpopulation exhibited unique characteristics, developmental trajectories, transcriptional regulation, and tissue distribution. In addition, alterations associated with cardiovascular disease (CVD) risk factors, including race, smoking, and hyperlipidemia were identified. Moreover, the effect of hyperlipidemia was recapitulated in mouse models of elevated cholesterol. This integrative and cross-species comparative analysis provides a new perspective on comparison of alterations in monocytes in pathological conditions and offers insights into monocyte-driven mechanisms in CVD and the potential for monocyte subpopulation targeted therapies.

2025-05-08 | GSE296624 | GEO

Single-cell multimodal profiling of monocytes reveals diverse phenotypes and alterations linked to cardiovascular disease risks

2024-07-29 | GSE269335 | GEO

Single-cell multimodal profiling of monocytes reveals diverse phenotypes and alterations linked to cardiovascular disease risks [CITE-seq]

2024-07-29 | GSE269478 | GEO

Platelet Reactivity ExpreSsion Score Predicts Cardiovascular Risk

Project description:Platelet Reactivity ExpreSsion Score Predicts Cardiovascular Risk

| PRJNA970668 | ENA

HYDROXYTYROSOL IN CARDIOVASCULAR RISK

Project description:MULTI-OMIC ANALYSIS AND PLATELET FUNCTION DISTINGUISH TREATMENT RESPONSES TO HYDROXYTYROSOL IN CARDIOVASCULAR RISK

| PRJEB84474 | ENA

Functional evaluation of neutrophil of patients at high risk for infection treated with monocyte/ neutrophil apheresis

Project description:Interventions: monocyte/neutrophil apheresis non monocyte/neutrophil apheresis Primary outcome(s): Evaluation neutrophil function of patients at high risk for postoperative infection treated with monocyte/neutrophil apheresis Study Design: Parallel Non-randomized

| 2627605 | ecrin-mdr-crc

Functional evaluation of neutrophil of patients at high risk for infection treated with multiple monocyte/ neutrophil aphaereses

Project description:Interventions: multiple monocyte/neutrophil apheresis non monocyte/neutrophil apheresis Primary outcome(s): Evaluation neutrophil function of patients at high risk for postoperative infection treated with monocyte/neutrophil apheresis Study Design: Parallel Non-randomized

| 2628620 | ecrin-mdr-crc

Cardiovascular risk in patients with type 2 diabetes is associated with alteration of blood monocyte phenotype and plasma metabolome

Project description:To gain insight into the relationship between circulating monocytes and cardiovascular risk (CV) progression in patients with type 2 diabetes (T2D), we collected blood monocytes (CD14 positive selection) from 92 people with type 2 diabetes and coronary artery calcium score (CAC-score). Gene expression profiles of circulating monocytes were assessed by RNA sequencing.

2024-01-08 | GSE201087 | GEO

Cardiovascular risk in patients with type 2 diabetes is associated with alteration of blood monocyte phenotype and plasma metabolome

Project description:Cardiovascular risk in patients with type 2 diabetes is associated with alteration of blood monocyte phenotype and plasma metabolome

| PRJNA828266 | ENA

Action to Control Cardiovascular Risk in Diabetes (ACCORD-BioLINCC)

Project description:Action to Control Cardiovascular Risk in Diabetes (ACCORD-BioLINCC)

| PRJNA1075471 | ENA