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Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells [Visium]

ABSTRACT: Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells [Visium]

PROVIDER: PRJNA1260472 | ENA |

REPOSITORIES: ENA

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Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

Project description:Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

| PRJNA1259376 | ENA

Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells [Visium]

Project description:In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that has been found to additionally possess the ability to control tissue homeostasis and repair. However, it is not known how these functions are molecularly controlled and if they are influenced by tumor metabolism. Here, we report that excessive release of polyamines in the tumor microenvironment directs the functional polarization of Treg cells towards immunosuppression in a protein kinase CK2 (CK2)-dependent manner. Polyamine deprivation as well as genetic or pharmacological inhibition of CK2 activity in Treg cells induced tissue reparative properties in Treg cells that orchestrated efficient antitumor type 2 immune responses, and coordinated tissue repair mechanisms to support tumor eradication. These findings suggest the potential for targeted modulation of Treg cell functions, offering new avenues for cancer therapy.

2025-07-30 | GSE296660 | GEO

Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells [scRNA-Seq]

Project description:Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells [scRNA-Seq]

| PRJNA1259916 | ENA

Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

2025-07-30 | GSE296432 | GEO

Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells [scRNA-Seq]

2025-07-30 | GSE296534 | GEO

Snapshot of translation in mammalian cells that are depleted of polyamines or replete with polyamines

Project description:Snapshot of translation in mammalian cells that are depleted of polyamines or replete with polyamines. Hek293T cells treated with DFMO or Spermidine.

2018-10-11 | GSE111517 | GEO

Subsoil specialization

Project description:Subsoil specialization in arbuscular mycorrhizal fungi

| PRJEB25819 | ENA

Targeting polyamines catabolism to counteract the detrimental effects of cellular senescence

Project description:To investigate the effect of pharmacological targeting of polyamines catabolic enzymes in the establishment and reversion of the senescent phenotype

2022-10-18 | GSE212085 | GEO

Snapshot of translation in mammalian cells that are depleted of polyamines or replete with polyamines

Project description:Snapshot of translation in mammalian cells that are depleted of polyamines or replete with polyamines

| PRJNA437287 | ENA

Spatially resolved transcriptomic profiling: an experimental comparison of GeoMx Digital Spatial Profiling and Visium CytAssist spatial transcriptomics in three cancer types (Chromium and Visium)

Project description:We performed Visium CytAssist (10X), GeoMx DSP (Nanostring) and Chromium Flex (10X Genomics) full transcriptome profiling on Breast Cancer (BC), Lung Cancer (LC) and diffuse large B cell lymphoma (DLBCL) samples from archival FFPE blocks. We explore the data quality across blocks with different storage times and DV200 values for all the three methods. We compared the cell type signature purity between ST methods Visium and GeoMx by utilising pathology annotations and scRNAseq. For the Visium and Chromium methods with a large number of data points we explored the heterogeneity between tissues. Finally, we demonstrate the discovery of patient-specific tumor-TME interactions across all three methods.

2024-11-01 | E-MTAB-14560 | biostudies-arrayexpress

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