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Restorative effect of adipose tissue-derived stem cells (ADSCs) on palmitic acid (PA)-activated IMS/N hepatic stellate cells

ABSTRACT: Restorative effect of adipose tissue-derived stem cells (ADSCs) on palmitic acid (PA)-activated IMS/N hepatic stellate cells

PROVIDER: PRJNA1260916 | ENA |

REPOSITORIES: ENA

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Restorative effect of adipose tissue-derived stem cells (ADSCs) on palmitic acid (PA)-activated IMS/N hepatic stellate cells

Project description:The restorative indirect effect of ADSCs on activated IMS/N hepatic stellate cells was evaluated by gene expression analysis (DNA microarray). IMS/N were stimulated by palmitic acid (PA), and the effect of media derived by cell culture of ADSCs was verified by gene expression analysis.

2025-06-19 | GSE296718 | GEO

Restorative effect of adipose tissue-derived stem cells (ADSCs) on IL17A-activated IMS/N hepatic stellate cells

Project description:The restorative indirect effect of ADSCs on activated IMS/N hepatic stellate cells was evaluated by gene expression analysis (DNA microarray). IMS/N were stimulated by IL17A, and the effect of media derived by cell culture of ADSCs was verified by gene expression analysis.

2025-06-19 | GSE296717 | GEO

Restorative effect of adipose tissue-derived stem cells (ADSCs) on IL17A-activated IMS/N hepatic stellate cells

Project description:Restorative effect of adipose tissue-derived stem cells (ADSCs) on IL17A-activated IMS/N hepatic stellate cells

| PRJNA1260918 | ENA

RNA sequence for macrodactyly ADSCs

Project description:Macrodactyly is a congenital malformation characterized by enlargement of bone and soft tissues in limbs, typically with excessive accumulation of adipose tissues. Although gain-of-function mutation of PIK3CA has been identified in macrodactyly, the mechanism of PIK3CA mutation in adipose accumulation is poorly understood. In this study, we found that adipocytes from macrodactyly were more hypertrophic than those observed in polydactyly. PIK3CA (H1047R) activating mutation and enhanced activity of PI3K/AKT pathway were detected in macrodactylous adipose-derived stem cells (Mac-ADSCs). To identify the key downstream effectors of PIK3CA activation-mediated adipogenesis in Mac-ADSCs, we examined the transcriptome of Mac-ADSCs, BYL-719 treated Mac-ADSCs and Pol-ADSCs by RNA-Seq analysis.

2020-06-05 | GSE151840 | GEO

Expression data from human adipose-derived stem cells (ADSCs)

Project description:Adipose-derived stem cells are angiogenic and attractive for therapeutic angiogenesis. However, ADSCs contain several subsets according to expression pattern of surface markers. We identified CD271 (LNGFR) can isolate ADSCs with superior capacity for angiogenesis. Therefore, we aimed to compare gene expression profile between CD271+ and CD271- ADSCs.

2019-01-14 | GSE125012 | GEO

RNA sequence for macrodactyly ADSCs

Project description:RNA sequence for macrodactyly ADSCs

| PRJNA637388 | ENA

Gene expression profiles of hexadecyl-4-124I-iodobenzoate(124I-HIB)-labeled adipose-derived stem cells (ADSCs) in vitro and in vivo

Project description:[1] Microarray analysis in the rat myocardial tissue: 124I-HIB transplanted MI model Vs. phosphate buffered saline (PBS) injected myocardial infarction (MI) model Vs. Sham operated model [2] Microarray analysis in the rat adipose derived stem cells: 124I-HIB-labeled ADSCs Vs. Unlabeled ADSCs [1] We investigated the change of gene expression profile in sham operated-, PBS injected- and 124I-HIB-labeled ADSCs transplanted myocardium in rat myocaridial infarction (MI) model. [2] We compared gene expression profile with 124I-HIB labeled ADSCs and unlabeled ADSCs in vitro.

2015-01-06 | E-GEOD-64692 | biostudies-arrayexpress

Expression data of genes and noncoding genes from the ADSCs and adipogenic-induced ADSCs

Project description:Expression data of genes and noncoding genes from the ADSCs and adipogenic-induced ADSCs

| PRJNA490336 | ENA

Expression data of genes and noncoding genes from the ADSCs and adipogenic-induced ADSCs

Project description:Adipogenesis participates in many physiological and pathological processes such as obesity and diabetes, and is regulated by a series of precise molecular events. However, the molecules involved in this regulation have not been fully characterized. We used microarrays to detail the full transcriptome expression profiles of undifferentiated and adipogenic-induced ADSCs.

2018-09-12 | GSE119796 | GEO

Glutamine influx licenses macrophage glutaminolysis for restorative functions in atherosclerosis

Project description:Atherosclerotic plaque macrophages are key players at the site of disease, where metabolic reprogramming dictates whether they ameliorate or exacerbate pathogenesis. Here, we found that glutamine synthetase served as a metabolic rheostat controlling nutrient flux into cells in vitro, macrophage restorative functions in the context of atherosclerosis relied more heavily on glutamine influx and glutaminase activity. Cell-intrinsic regulation of glutaminolysis drives macrophage metabolic and transcriptional rewiring in atherosclerosis by diverting exogenous Gln flux to balance remodeling and restorative functions. Thus, we uncover a role of glutamine uptake upstream of glutaminolysis in atherosclerotic plaque development and stability.

2025-09-01 | GSE302738 | GEO

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