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Preclinical and first-in-human of Purinostat Mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed or refractory multiple myeloma and lymphoma [PDX]

ABSTRACT: Preclinical and first-in-human of Purinostat Mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed or refractory multiple myeloma and lymphoma [PDX]

PROVIDER: PRJNA1261791 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR33536127_1.fastq.gz	Fastqsanger.gz
	SRR33536127_2.fastq.gz	Fastqsanger.gz
	SRR33536128_1.fastq.gz	Fastqsanger.gz
	SRR33536128_2.fastq.gz	Fastqsanger.gz
	SRR33536129_1.fastq.gz	Fastqsanger.gz

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Preclinical and first-in-human of Purinostat Mesylate, a novel selective HDAC I/IIb inhibitor, in relapsed or refractory multiple myeloma and lymphoma [PDX]

Project description:Purinostat Mesylate (PM), a highly selective HDAC I/IIb inhibitor, exhibits excellent antitumor activity in multiple MM and lymphoma cell lines and multiple mouse models, outperforming the pan-HDAC inhibitor panobinostat or first-line/second-line multi-drug combinations. Different from panobinostat, bulk RNA-seq analysis results revealed that PM targeted essential tumor survival factors, and triggered inflammation and interferon responses. ScRNA-seq of 5TMM models further indicated that PM enhanced antitumor immunity by boosting monocyte- and T cell-mediated immune responses.

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