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Disrupted MOS signaling alters meiotic cell cycle regulation and the egg transcriptome

ABSTRACT: Disrupted MOS signaling alters meiotic cell cycle regulation and the egg transcriptome

PROVIDER: PRJNA1263829 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR33610500_1.fastq.gz	Fastqsanger.gz
	SRR33610500_2.fastq.gz	Fastqsanger.gz
	SRR33610501_1.fastq.gz	Fastqsanger.gz
	SRR33610501_2.fastq.gz	Fastqsanger.gz
	SRR33610502_1.fastq.gz	Fastqsanger.gz

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Disrupted MOS signaling alters meiotic cell cycle regulation and the egg transcriptome

Project description:Loss of MOS in female mice disrupts metaphase II arrest, potentially causing infertility and germ cell tumors. Single-egg RNA sequencing revealed widespread gene expression changes in mos -/- eggs, including upregulation of cell cycle regulators like Aurka, Bub3, and Cdk7. Pathways related to RNA metabolism, transcription, and neddylation were also enriched in mos -/- eggs. Notably, the transcriptome of mos -/- eggs differed from that of chemically activated eggs. These results highlight MOS as a key regulator of the meiotic cell cycle and transcriptome integrity essential for oocyte developmental competence.

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Expression data comparing human DKK1 and control vector transfected murine osteochondrosarcoma cells (MOS-J)

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