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CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection [Cthrc1_wt_ko_RNAseq]

ABSTRACT: CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection [Cthrc1_wt_ko_RNAseq]

PROVIDER: PRJNA1265128 | ENA |

REPOSITORIES: ENA

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CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection [Cthrc1_wt_ko_RNAseq]

Project description:Aortic dissection (AD) is a cardiovascular disease with rapid onset and extremely high short-term mortality, currently lacking specific peripheral blood-based biomarkers and effective treatments. Here, our analyses of AD samples from animal models and human patients revealed elevated blood levels of CTHRC1, a protein secreted by vascular fibroblasts. Furthermore, CTHRC1 regulates the phenotypic switch of vascular smooth muscle cells (VSMCs) during arterial remodeling by binding to ADAM9 on the VSMC membrane, activating the ERK1/2 signaling pathway, and promoting a contractile-to-synthetic transition. In Ang-II/BAPN induced AD mouse models, genetic ablation or antibody-mediated blockade of CTHRC1 effectively prevented AD formation and development. These findings unveil activated vascular fibroblast derived CTHRC1 as a critical regulator of VSMC phenotype and aortic structural integrity via the ERK1/2 signaling pathway, suggesting its potential as a novel serum diagnostic biomarker for AD diagnostic and a promising therapeutic target. Collectively, our data propose a new and effective strategy for diagnosis and clinical management of patients with AD.

2025-08-19 | GSE297518 | GEO

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection [Ab_mouse_RNAseq]

2025-08-19 | GSE297520 | GEO

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection [MOVAS_rhCTHRC1_RNAseq]

2025-08-19 | GSE297519 | GEO

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

Project description:CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

| PRJNA1268468 | ENA

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection [MOVAS_rhCTHRC1_RNAseq]

Project description:CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection [MOVAS_rhCTHRC1_RNAseq]

| PRJNA1265124 | ENA

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection [Ab_mouse_RNAseq]

Project description:CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection [Ab_mouse_RNAseq]

| PRJNA1265127 | ENA

Circulating microRNAs: a novel potential biomarker for diagnosing acute aortic dissection

Project description:Microarrays with 1,205 human microRNAs and 142 viral microRNAs were used for screening candidate diagnostic markers in the 3 categories of subjects from 24 plasma samples including acute aortic dissection, healthy and aortic aneurysm subjects. There were two microRNAs overlapping in the 3 group comparisons. Finally, 16 candidate microRNAs discovered via microarrays were selected for the further validation.

2017-11-15 | GSE92427 | GEO

CTHRC1 is a new therapeutic target and serum diagnostic biomarker for aortic dissection

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-08-19 | GSE298176 | GEO

Expression data from control, aortic aneurysm, and aortic dissection cells

Project description:Aneurysmatic and dissection cells show a specific alteration of gene expression, which allow a disease specific distinction. We used microarrays to analyse the cellular gene expression of controls, thoracic aortic aneurysm, and aortic dissection.

2022-12-02 | GSE219204 | GEO

Epigenome analysis of ascending aorta from normal, aortic dissection and bicuspid aortic valve patients

Project description:Genome wide DNA methylation profiling of ascending aorta tissue samples from normal, aortic dissection and bicuspid aortic valve patients with aortic dilation. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across more than 450,000 CpGs in ascending aorta samples. Samples included 6 normal donors, 12 patients with aortic dissection and 6 patients with bicuspid aortic valve and dilated aorta.

2019-07-11 | GSE84274 | GEO

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