Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1265929 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR33651561_subreads.fastq.gz | Fastqsanger.gz | |||
| SRR33651562_subreads.fastq.gz | Fastqsanger.gz | |||
| SRR33651563_subreads.fastq.gz | Fastqsanger.gz | |||
| SRR33651564_subreads.fastq.gz | Fastqsanger.gz | |||
| SRR33651565_subreads.fastq.gz | Fastqsanger.gz |
Items per page: 5 1 - 5 of 37 |
Similar Datasets
Project description:Salmonella being one of the major infectious diseases in poultry causes considerable economical losses in terms of mortality and morbidity especially in countries which lack effective vaccination programs. Salmonellosis is considered to be most important zoonotic disease which causes considerable foodborne illness that leads to enormous economic loses. To minimize such losses, enhancing disease resistance to different pathogens seems to be a promising strategy. The indigenous chicken, evolved through thousands of years of natural selection, are well adapted to the local climatic conditions with better resistance to diseases. In the present study we investigated liver and spleen transcriptome profile of indigenous (Kashmir faverolla) breed and commercial broiler poultry at day 5 post-inoculation with Salmonella typhimurium using RNA sequencing. The DEGs and pathways identified shall provide potential targets to enhance disease resistance in poultry through successful breeding programmes.
2022-02-01 | GSE168060 | GEO
Project description:The non-typhoidal Salmonella enterica serotype Heidelberg is a major foodborne pathogen primarily transmitted to humans through contaminated poultry products. Current control measures emphasize novel approaches to mitigate Salmonella Heidelberg colonization in poultry and the contamination of poultry products, thereby reducing its transmission to humans. This study highlight that commensal E. coli 47-1826 can potentially be used to control of S. Heidelberg 18-9079 in poultry
2024-09-17 | GSE276976 | GEO
Project description:The gut microbiota exerts profound influence on poultry immunity and metabolism through mechanisms that yet need to be elucidated. Here we used conventional and germ-free chickens to explore the influence of the gut microbiota on transcriptomic along the gut-lung axis in poultry. Our results demonstrated a differential regulation of genes associated with innate immunity and metabolism in the spleen of germ-free birds.
2024-08-28 | E-MTAB-14264 | biostudies-arrayexpress
Project description:The gut microbiota exerts profound influence on poultry immunity and metabolism through mechanisms that yet need to be elucidated. Here we used conventional and germ-free chickens to explore the influence of the gut microbiota on transcriptomic along the gut-lung axis in poultry. Our results demonstrated a differential regulation of genes associated with innate immunity and metabolism in the lungs of germ-free birds.
2024-08-28 | E-MTAB-14261 | biostudies-arrayexpress
Project description:The gut microbiota exerts profound influence on poultry immunity and metabolism through mechanisms that yet need to be elucidated. Here we used conventional and germ-free chickens to explore the influence of the gut microbiota on transcriptomic along the gut-lung axis in poultry. Our results demonstrated a differential regulation of genes associated with innate immunity and metabolism in the caeca of germ-free birds.
2024-08-28 | E-MTAB-14262 | biostudies-arrayexpress
Project description:H5N8 influenza virus is a highly pathogenic pathogen for the poultry and human. Vaccination is the most effective method to control the spread of the virus right now. The traditional inactivated vaccine, though well developed and used widely, is laborious during application and more interests are stimulated in developing alternative approaches. In this study, we developed three HA gene-based yeast vaccines and our experimental results demonstrated that all of these vaccines elicited the humoral immunity, inhibited viral load in the chicken tissues, and provided protective efficacy partially due to the high dose of H5N8 virus. Molecular mechanism studies suggested that, compared to the traditional inactivated vaccine, our engineered yeast vaccines reshaped the immune cell microenvironment in bursa of Fabriciu to promote the defense and immune responses. Analysis of gut microbiota further suggested that oral administration of engineered ST1814G/H5HA yeast vaccines increased the diversity of gut microbiota and the increasement of Reuteri and Muciniphila might benefit the recovery from influenza virus infection. These results provide strong evidences for further clinical use of these engineered yeast vaccines in poultry.
2023-01-01 | GSE220714 | GEO
Project description:Campylobacter jejuni is a common cause of diarrheal disease worldwide. Human infection typically occurs through the ingestion of contaminated poultry products. We previously demonstrated that an attenuated Escherichia coli live vaccine strain expressing the C. jejuni N-glycan on its surface reduces the Campylobacter load in more than 50% of vaccinated leghorn and broiler birds to undetectable levels (responder birds), whereas the remainder of the animals were still colonized (non-responders). To understand the underlying mechanism, we conducted 3 larger scale vaccination and challenge studies using 135 broiler birds and found a similar responder/non responder effect. The submitted data were used for a genome-wide association study of the chicken responses to glycoconjugate vaccination against Campylobacter jejuni.
2021-11-01 | GSE181619 | GEO
Project description:Hanl Lee & Angelyn Lao. Transmission dynamics and control strategies assessment of avian influenza A (H5N6) in the Philippines. Infectious Disease Modelling 3 (2018).
Due to the outbreaks of Highly Pathogenic Avian Influenza A (HPAI) H5N6 in the Philippines (particularly in Pampanga and Nueva Ecija) in August 2017, there has been an increase in the need to cull the domestic birds to control the spread of the infection. However, this control method poses a negative impact on the poultry industry. In addition, the pathogenicity and transmissibility of the H5N6 in both the birds and the humans remain largely unknown which call for the necessity to develop more strategic control methods for the virus. In this study, we constructed a mathematical model for the bilinear and half-saturated incidence to compare their corresponding effect on transmission dynamics of H5N6. The simulations of half-saturated incidence model were similar to what occurred during the H5N6 outbreak (2017) in the Philippines. Instead of culling the birds, we implemented other control strategies such as non-medicinal (personal protection and poultry isolation) and medicinal (poultry vaccination) ways to prevent, reduce, and control the rate of the H5N6 virus transmission. Among the proposed control strategies, we have shown that the poultry isolation strategy is still the most effective in reducing the infected birds.
2024-09-02 | BIOMD0000000716 | BioModels
Project description:Hanl Lee & Angelyn Lao. Transmission dynamics and control strategies assessment of avian influenza A (H5N6) in the Philippines. Infectious Disease Modelling 3 (2018).
Due to the outbreaks of Highly Pathogenic Avian Influenza A (HPAI) H5N6 in the Philippines (particularly in Pampanga and Nueva Ecija) in August 2017, there has been an increase in the need to cull the domestic birds to control the spread of the infection. However, this control method poses a negative impact on the poultry industry. In addition, the pathogenicity and transmissibility of the H5N6 in both the birds and the humans remain largely unknown which call for the necessity to develop more strategic control methods for the virus. In this study, we constructed a mathematical model for the bilinear and half-saturated incidence to compare their corresponding effect on transmission dynamics of H5N6. The simulations of half-saturated incidence model were similar to what occurred during the H5N6 outbreak (2017) in the Philippines. Instead of culling the birds, we implemented other control strategies such as non-medicinal (personal protection and poultry isolation) and medicinal (poultry vaccination) ways to prevent, reduce, and control the rate of the H5N6 virus transmission. Among the proposed control strategies, we have shown that the poultry isolation strategy is still the most effective in reducing the infected birds.
2024-09-02 | BIOMD0000000717 | BioModels
Project description:This is a dynamic mathematical model describing the development of the cellular branch of the intestinal immune system of poultry during the first 42 days of life, and of its response towards an oral infection with Salmonella enterica serovar Enteritidis.
2024-09-02 | BIOMD0000000895 | BioModels