Project description:The research of DSE on soil and root microorganisms of Astragalus membranaceus var. mongholicus under drought and rehydration conditions
| PRJNA1266102 | ENA
Project description:Effects of DSE on soil microorganisms of Astragalus membranaceus var. mongholicus
| PRJNA1250968 | ENA
Project description:Effects of DSE on soil microorganisms of Astragalus membranaceus var. mongholicus under drought and cadmium stress
Project description:To identify biomarkers regulated by traditional Chinese medicine Astragalus membranaceus Fischer Bge. var. mongolicus Bge. Hsiao in colorectal cancer. We have identified several differentially expressed genes including microRNAs using Affymetrix HTA-2.0 array. In this dataset, we include the expression data obtained from colon cancer cell line HCT116 grafted into nude mice. The mice was treated either water or traditional Chinese medicine Astragalus membranaceus for 28 days. These data are used to obtain 1425 genes that are differentially expressed in response to Astragalus membranaceus treatment.
Project description:Plants coexist in close proximity with numerous microorganisms in their rhizosphere. With certain microorganisms, plants establish mutualistic relationships that can confer physiological benefits to the interacting organisms, including enhanced nutrient assimilation or increased stress tolerance. The root-colonizing endophytic fungi Penicillium chrysogenum, Penicillium minioluteum, and Serendipita indica have been reported to enhance the drought stress tolerance of plants. However, to date, the molecular mechanisms triggered by these fungi in plants remain unexplored. This study presents a comparative analysis of the effects on mock- and fungus-infected tomato plants (var. Moneymaker) under drought stress conditions (40% field capacity) and control conditions (100% field capacity). The findings provide evidence for the induction of common response modules by the fungi.
Project description:Astragali Radix (AR) is a commonly used herbal drug in Traditional Chinese Medicine, and widely used for the treatment of diabetes, cardiovascular diseases, nephropathy and neuropathy. The main source of AR is the dried root of Astragalus membranaceus var. mongholicus (Bge.) Hsiao in China, and both cultivated and wild ARs are used in the clinic. Systematic comparison of cultivated AR and wild AR should be performed to ensure the efficacy and safety in clinic. In this study, the chemical compositions of two different ARs, collected in Shanxi (wild) and Gansu (cultivated) Provinces, were compared by NMR based metabolic fingerprint coupled with multivariate analysis. Then SX-AR and GS-AR induced metabolic changes of endogenous metabolites in mice were also compared. The results showed that SX-AR and GS-AR differed significantly not only in the primary metabolites, but also the secondary metabolites. However, alterations of endogenous metabolites in serum, lung, liver and spleen were relatively small between them. This study provided a novel and valuable method for consistency and diversity evaluation of herbal drugs, and further studies should be conducted on the difference of polysaccharide as well as biological effect between the two kinds of ARs.
2017-01-16 | MTBLS189 | MetaboLights
Project description:Transcriptome sequencing of Astragalus membranaceus var. mongholicus adventitious roots exposed to green leaf volatiles
