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Chemical reprogramming of human blood cells into hCiPS cells [scRNA-seq]

ABSTRACT: Chemical reprogramming of human blood cells into hCiPS cells [scRNA-seq]

PROVIDER: PRJNA1268522 | ENA |

REPOSITORIES: ENA

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Chemical reprogramming of human blood cells into hCiPS cells [scRNA-seq]

Project description:Chemical reprogramming offers a fundamentally innovative approach for generating human pluripotent stem (hCiPS) cells using small molecules. Our recent studies showed that this approach was highly efficient in reprogramming human fibroblasts to hCiPS cells. In this study, we established a robust method that successfully generated hCiPS cells from both cord blood and adult peripheral blood cells. This method achieved efficient reprogramming with both fresh and cryopreserved blood cells.

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Chemical reprogramming of human blood cells into hCiPS cells

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Establish a rapid and efficient chemical reprogramming platform [scRNA-Seq]

Project description:Chemically reprogramming somatic cells to iPSCs is time-consuming and low-efficiency. Here, we discribe a rapid chemical reprogramming condition enabling generating iPSCs from MEFs in 12 days. To further investigate the mechemisms and draw an epigenetic maps during the rapid chemical reprogramming, we performed time-course RNA-seq, ATAC-seq, RRBS, CUT&Tag (H3K4me3, H3K18la, H3K9me3, H3K27me3 and H3K27ac) and scRNA-seq.

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Chemical reprogramming of human blood cells into hCiPS cells [bulk ATAC-seq]

Project description:Chemical reprogramming of human blood cells into hCiPS cells [bulk ATAC-seq]

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Chemical reprogramming of human blood cells into hCiPS cells [bulk RNA-seq]

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Chemical reprogramming of fibroblasts into functional retinal pigment epithelium cells (scRNA-seq)

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Efficient Chemical Reprogramming of Human T Cells into Functional Megakaryocytes and Platelets

Project description:The generation of megakaryocytes (MKs) from human somatic cells through chemical reprogramming represents a promising strategy for developing alternative platelet sources. Building on our prior chemical reprogramming protocol for converting erythroblasts to MKs, we established a robust method that successfully generated induced MKs (iMKs) from human cord blood-derived CD3⁺ T cells, which is a more abundant source. This method utilized a five- small-molecule (5M) cocktail containing a reprogramming booster, AZD4205, to promote erasure of T cell identity and facilitate fate transition towards MKs. T cell-derived iMKs exhibited characteristic MK cellular and molecular signatures, demonstrating the capacity to produce proplatelets and release functional platelets in vitro and in vivo. ScRNA-sequencing further revealed that iMKs were heterogeneous with distinct functional profiles, including cycling, immune, and thrombopoiesis-biased MKs. Our findings highlight an optimized chemical reprogramming pathway that enables efficient conversion of T cells to MKs, providing a practical and convenient approach to generate clinically relevant MKs and platelets.

2025-11-27 | GSE310060 | GEO

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