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FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single-Cell Perspective

ABSTRACT: FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single-Cell Perspective

PROVIDER: PRJNA1269944 | ENA |

REPOSITORIES: ENA

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	SRR33764422_1.fastq.gz	Fastqsanger.gz
	SRR33764422_2.fastq.gz	Fastqsanger.gz
	SRR33764423_1.fastq.gz	Fastqsanger.gz
	SRR33764423_2.fastq.gz	Fastqsanger.gz

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FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single-Cell Perspective

Project description:We performed single-cell RNA sequencing to analyze murine lung tissues exposed to either conventional dose rate (CONV) or FLASH radiation therapy (FLASH-RT). This approach elucidated distinct early immune responses in radiation-induced lung injury and revealed protective mechanisms specific to FLASH irradiation. Systematic characterization of over 135,000 cells within the pulmonary microenvironment uncovered critical immune and stromal cell dynamics that differentiate CONV and FLASH-RT responses. These findings provide mechanistic insights into FLASH-RT's biological effects and its potential clinical applications in thoracic oncology.

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FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single-Cell Perspective.

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Expression data from LT-HSCs from bone marrow non-irradiated, 8Gy CDR and 8Gy FLASH total body irradiated mice

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