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Roles of DNA hydroxymethylation versus DNA formylation and carboxylation in neural stem cells [CUT&Tag]

ABSTRACT: Roles of DNA hydroxymethylation versus DNA formylation and carboxylation in neural stem cells [CUT&Tag]

PROVIDER: PRJNA1270073 | ENA |

REPOSITORIES: ENA

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Roles of DNA hydroxymethylation versus DNA formylation and carboxylation in neural stem cells [CUT&Tag]

Project description:TET enzymes are highly expressed in neural stem cells (NSCs). They oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) in a step-wise manner. In this study we have generated NSCs that only lack the Tet formylation and carboxylation activities (Tet-TFoCa) and have compared their multipotency, transcriptome and epigenome to NSCs that lacked all three Tet activities (Tet-TMut). Our findings reveal unique roles for DNA hydroxymethylation vs DNA formylation and carboxylation in multipotency of NSCs.

2025-07-14 | GSE298639 | GEO