Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: gut microbiota and premature ovarian insufficiency

PROVIDER: PRJNA1272892 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR33855300_1.fastq.gz	Fastqsanger.gz
	SRR33855300_2.fastq.gz	Fastqsanger.gz
	SRR33855301_1.fastq.gz	Fastqsanger.gz
	SRR33855301_2.fastq.gz	Fastqsanger.gz
	SRR33855302_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Homozygosity mapping in family segregating premature ovarian insufficiency (POI)

Project description:Premature ovarian insufficiency (POI) is defined as a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles before the age of 40 (secondary amenorrhea) with hypergonadotropism and hypoestrogenism. Premature ovarian insufficiency has few known genetic causes but in familial cases a genetic link is often suspected. A large consanguineous family with three female affected with POI was investigated. All samples including 3 affected and 5 unaffecd underwent whole genome SNP genotyping using Affymetric Axiom_GW_Hu_SNP array. Linkage analysis was carried out using HomozygosityMapper and Allegro softwares.Linkage analysis mapped the disease phenotype to long arm of chromosome 20. Sequence data analysis of potential candidate genes failed to detect any pathogenic variant.

2014-03-20 | GSE56043 | GEO

Differences in miRNA expression profiles of follicular fluid exosomes between Premature ovarian insufficiency and normal ovarian reserve

Project description:Premature ovarian insufficiency (POI) refers to the severe decline and failure of ovarian function in women before the age of 40, and current treatment methods have significant limitations. In order to screen miRNAs with good anti-apoptotic effect, we used high-throughput sequencing technology to study the differences in exosomal miRNA expression profiles from human follicular fluid between patients with POI and patients with normal ovarian reserve.

2024-12-01 | GSE253684 | GEO

Eif2s2 deficiency causes oocyte arrest at the early diplotene stage and apoptosis in mice

Project description:Mutations in translation initiation factors are associated with premature ovarian insufficiency. Here, we used signle-cell RNA sequencing method to investigate the effect of Eif2s2 deletion in premeiotic germ-cells on primordial formation.

2024-12-18 | GSE263836 | GEO

Differentially expressed mRNA in biological premature ovarian insufficiency (bPOI)

Project description:Differentially expressed mRNA in biological premature ovarian insufficiency (bPOI)

| PRJNA830696 | ENA

Differentially expressed lncRNA in biological premature ovarian insufficiency (bPOI)

Project description:Differentially expressed lncRNA in biological premature ovarian insufficiency (bPOI)

| PRJNA559738 | ENA

Homo sapiens

Project description:Differentially expressed miRNA in biological premature ovarian insufficiency (bPOI)

| PRJNA391142 | ENA

Homo sapiens

Project description:Homozygosity mapping in family segregating premature ovarian insufficiency (POI)

| PRJNA242288 | ENA

Identify urinary exosome microRNAs that are unique to premature ovarian insufficiency

Project description:This study is to identify urinary exosome microRNAs (miRNAs) that are unique to premature ovarian insufficiency (POI) with and without Turner syndrome and to use them as diagnostic markers for POI patients. We examined the miRNAexpression profile in urine exosomes from POI patients with and without Turner syndrome.

2022-09-28 | GSE205700 | GEO

The Impact of Gut Microbiota in Anastomoses Insufficiency After Resection and Direct Anastomosis for Colorectal Cancer.

Project description:The role of gut microbiota in anastomosis insufficiency in patients operated for colorectal cancer and for peritoneal carcinomatosis is going to be investigated. This is a pilot study.

| 2328802 | ecrin-mdr-crc

Transcriptome analysis of cardiac tissues from mice subjected to SD model with oxygen therapy

Project description:Adequate sleep is essential for relieving stress and rejuvenating the mind; however, undesirable physiological and pathological responses resulting from sleep insufficiency or sleep deprivation (SD) are becoming increasingly common. However, the influence of sleep deficiency on gut microbiota and microbiota-associated human diseases, especially on cardiac diseases remain controversial. Here, we constructed the experimental SD model in mice and found it significantly resulted in weakness, depression-like behaviors, and multiple organs dysfunction. Intriguingly, SD mice developed pathogenic cardiac hypertrophy and fibrosis with poor ejection fraction as well as fractional shortening. 16s rRNA sequencing demonstrated that SD-induced the pathogenic effects of gut microbiota, which was also observed in mice received by fecal microbe from SD mice in fecal microbiota transplantation (FMT) assays. Next, we investigated the therapeutic effects and underlying mechanisms of oxygen therapy in gut microbiota-associated cardiac fibrosis and dysfunction. The environment of 30% oxygen concentration effectively ameliorated the pathological effects on cardiac function. Transcriptome data also found oxygen therapy targeted several hypoxia-dependent pathways and suppressed cardiac collagen production. In conclusion, these results indicated the importance of sufficient sleep in gut microbiota and may represent a potential therapeutic strategy of oxygen environment exerts protective effects in sleepless sufferings through gut microbiota.

2025-03-25 | GSE284746 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data