Project description:Neuronal sub-type diversity in the hypothalamus is staggeringly immense. To investigate the role of epigenetic regulation in hypothalamic development in the generation of this cellular diversity; a floxed Eed allele was crossed to the early, pan-CNS Cre deleter Sox1-Cre, resulting in loss of H3K27me3 in the entire Mus musculus CNS by E11.5. The E18.5 embryonic hypothalamus was dissected and analysed by single cell RNA sequencing, on the Illimina/BioRad platform. Cell specification was surprisingly unaffected, with the majority of cell types - except Hcrt and dopamine neurons - sucessfully generated. This indicates that the role of the PRC2 complex - past E11.5 - is surprisingly limited in Mus musculus hypothalamic development.

2022-02-14 | GSE154995 | GEO

Mus musculus breed:C57

Project description:Mus musculus breed:C57 Transcriptome or Gene expression

| PRJNA1286117 | ENA

Mus musculus breed:C57

Project description:Mus musculus breed:C57 Transcriptome or Gene expression

| PRJNA1286125 | ENA

Mus musculus breed:C57/BL6

Project description:Mus musculus breed:C57/BL6 Epigenomics

| PRJNA281127 | ENA

Mus musculus strain:B6

Project description:Mus musculus Epigenomics mouse midbrain cut&tag

| PRJNA1042946 | ENA

Contrasting patterns of expression divergence in early and late stages of population divergence in mice

Project description:We compared gene expression differences in the polytypic species complex Mus musculus (Mus musculus musculus, Mus musculus domesticus, Mus musculus castaneus and Mus musculus ssp) with that of Mus spretus via oligonucleotide microarrays representing more than 20,000 genes. Analysis of the results by two way ANOVA statistics suggests that the most genes with significant differences in expression levels among the subspecies are found in liver and kidney and the least in testis. This picture is different when one compares with Mus spretus, where the largest number of differences is found in testis. Keywords: multi-species comparison

2006-12-13 | GSE2597 | GEO

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