Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Project description:The diurnal motion of higher plants, responding to the alternation of day and night, known as nyctinastic movements or "sleep movements", has been discussed frequently. We present the first description of the circadian rhythm of the water plant Ludwigia sedoides (Humb. & Bonpl.) H.Hara of the family Onagraceae, furthermore its morphology and anatomy. Our results indicate that the plant's movements are endogenous, although environmental factors certainly have an influence. The majority of plants with nyctinastic leaf movements have a pulvinus, as the crucial part of the plant enabling this movement. Although the basal section of the L. sedoides petiole is not swollen, the tissue functions similarly to a pulvinus. It consists of a central conducting tissue with thick-walled cells, which is surrounded by thin-walled motor cells that can undergo visible shrinking and swelling. Thus, the tissue functionally corresponds to a pulvinus. Examinations of cellular processes, like measurements of the turgor pressure in the petiole, need to be evaluated in future studies.
Project description:In 1953, Hara provided new combinations for many sectional and species names when he combined Jussiaea L. with Ludwigia L., and at the time, Ludwigiasect.Oligospermum (Micheli) H.Hara was the correct name for one well-defined section. However, subsequent changes to/clarifications of the botanical code have necessitated a change for that name in that now an autonym is treated as having priority over the name or names of the same date and rank that established it. Since Hara's combination was based on Jussiaeasect.Oligospermum Micheli, the correct name for this section is Ludwigiasect.Jussiaea (L.) Hoch, W.L.Wagner, & P.H.Raven.