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Effects of Ilex paraguariensis extracts on osteogenesis and bone microenvironment in mouse osteoblasts (MC3T3-E1)

ABSTRACT: Effects of Ilex paraguariensis extracts on osteogenesis and bone microenvironment in mouse osteoblasts (MC3T3-E1)

PROVIDER: PRJNA1285330 | ENA |

REPOSITORIES: ENA

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Effects of Ilex paraguariensis extracts on osteogenesis and bone microenvironment in mouse osteoblasts (MC3T3-E1)

Project description:Osteoporosis is a metabolic disease characterized by the destruction of bone microarchitecture and bone loss, which increases the risk of fractures and reduces quality of life. Understanding the biological mechanisms that promote bone formation is therefore of great importance. In this study, we performed transcriptomic sequencing to molecularly elucidate the effects of Ilex paraguariensis extracts on bone formation and bone-related health. Thus, this study identifies the potential mechanisms by which Ilex paraguariensis and Ligularia fischeri extracts influence bone formation and the bone microenvironment and suggests potential targets and benchmarks for biological research.

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Akap11 is a positive regulator of osteogenesis in mouse osteoblastic cell line MC3T3-E1

Project description:Purpose: This is a post-GWAS functional study that aims to determine the effect of Akap11 knockout in mouse preosteoblastic cell line MC3T3-E1 during osteogenesis. Methods: mRNA profile of WT (treated with CRISPR and remains unedited) and Akap11 knockout MC3T3-E1 cells were generated by RNAseq from pooled RNA (from 3 biological triplicate at equal quantity) of various timepoint during osteogenesis (Day 0, 7,16, 25).100ng total RNA was used for library construction by KAPA Stranded mRNA-Seq Kit (Roche). Pair-End 101bp sequencing was performed in the Illumin HiSq1500 sequencer using the HiSeq SBS Kit v4 (Illumina). Data was collected with SCS version 1.4.8. Base calling was performed using Illumina’s RTA (Version 1.12.4.2). 7 samples were sequenced per lane and achieved a sequencing depth of ~65 million read per sample. Results: Expression of osteogentic markers in Akap11 knockout MC3T3-E1 cells were suppressed. Genes invovled in IGF-I signaling pathway were signficantly altered.

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Tumor-derived Jagged1- and Notch-dependent transcription changes in MC3T3-E1 osteoblasts

Project description:Transcriptional profiling of MC3T3-E1 osteoblasts that were flow cytometry-separated from cocultures with control or Jagged1-overexpressing tumor cells and treated with either DMSO control or 1μM MRK-003 (gamma-secretase inhibitor). One cell line (MC3T3-E1) cells: four different experimental conditions: cultured with (1) control tumor cells + DMSO; (2) Jagged1-overexpressing tumor cells + DMSO; (3) control tumor cells + MRK-003; (4) Jagged1-overexpressing tumor cells + MRK-003. Each experiment has two biological replicates. Total, 8 samples.

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Project description:Effects of Ilex paraguariensis and Ligularia fischeri extracts on osteogenesis and bone microenvironment in mouse osteoblasts (MC3T3-E1)

| PRJNA1284002 | ENA

Mus musculus

Project description:Effects of Ilex paraguariensis and Ligularia fischeri extracts on osteogenesis and bone microenvironment in mouse osteoblasts (MC3T3-E1)

| PRJNA1284001 | ENA

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