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Thyroid Hormone Promotes Fetal Neurogenesis [bulk RNA-Seq]

ABSTRACT: Thyroid Hormone Promotes Fetal Neurogenesis [bulk RNA-Seq]

PROVIDER: PRJNA1304555 | ENA |

REPOSITORIES: ENA

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Thyroid Hormone Promotes Fetal Neurogenesis [CosMx]

Project description:Thyroid Hormone Promotes Fetal Neurogenesis [CosMx]

| PRJNA1308950 | ENA

Thyroid Hormone Promotes Fetal Neurogenesis [bulk RNA-Seq]

Project description:Maternal low thyroxine (T4) serum levels during the first trimester of pregnancy correlate with cerebral cortex volume and mental development of the progeny, but why neural cells during early fetal brain development are vulnerable to maternal T4 levels remains unknown. In this study, using iPSCs obtained from a boy with a loss-of-function mutation in MCT8—a transporter previously identified as critical for thyroid hormone uptake and action in neural cells—we demonstrate that thyroid hormones induce transcriptional changes that promote the progression of human neural precursor cells along the dorsal projection trajectory. Consistent with these findings, single-cell, spatial, and bulk transcriptomics from MCT8-deficient cerebral organoids and cultures of human neural precursor cells underscore the necessity for optimal thyroid hormone levels for these cells to differentiate into neurons. The controlled intracellular activation of T4 signaling occurs through the transient expression of the enzyme type 2 deiodinase, which converts T4 into its active form, T3, alongside the coordinated expression of thyroid hormone nuclear receptors. The intracellular activation of T4 in NPCs results in transcriptional changes important for their division mode and cell cycle progression. Thus, T4 is essential for fetal neurogenesis, highlighting the importance of adequate treatment for mothers with hypothyroidism.

2025-08-11 | GSE305186 | GEO

Thyroid Hormone Promotes Fetal Neurogenesis [scRNA-Seq]

Project description:Thyroid Hormone Promotes Fetal Neurogenesis [scRNA-Seq]

| PRJNA1303443 | ENA

Thyroid Hormone Promotes Fetal Neurogenesis [CosMx]

2025-08-22 | GSE305978 | GEO

Thyroid Hormone Promotes Fetal Neurogenesis [scRNA-Seq]

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The type 3 deiodinase contributes to the reduced sensitivity of the fetal brain to thyroid hormone

Project description:We examined the impact of thyroid hormone on the mouse fetal brain utilizing a model of deficiency in DIO3, the enzyme that is responsible for clearing thyroid hormones

2021-06-24 | GSE172000 | GEO

Thyroid hormone receptor beta1 action in the resolution of liver fibrosis [bulk RNA-seq]

Project description:Bulk RNAseq of liver from mice control and with hepatocyte specific ablation of the thyroid hormone receptor beta

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The thyroid hormone clearing type 3 deiodinase protects from cardiac congenital abnormalities

Project description:We examined the impact of thyroid hormone excess on the mouse fetal heart utilizing a model of deficiency in DIO3, the enzyme that is responsible for clearing thyroid hormones

2022-11-23 | GSE198416 | GEO

Thyroid hormone receptor beta is required for thyrotrpin regulation and thyroid hormone production.

Project description:Thyroid hormone receptor beta is required for thyrotrpin regulation and thyroid hormone production.

| PRJNA703005 | ENA

Thyroid hormone receptor alpha is required for thyroid hormone-dependent neural cell proliferation during tadpole metamorphosis

Project description:Using tadpoles mutant for thyroid hormone receptor alpha (thra), we show that TRa is required for thyroid hormone (T3) induction of cell proliferation in the brain. RNA-sequencing showed that the TRa is required for 95% of the gene regulation responses to T3.

2019-05-13 | GSE130816 | GEO

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