Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Vertebral Bone Marrow Transplant from a Deceased Lung Transplant Donor: Durable Hematopoiesis and Immune Tolerance

ABSTRACT: Vertebral Bone Marrow Transplant from a Deceased Lung Transplant Donor: Durable Hematopoiesis and Immune Tolerance

PROVIDER: PRJNA1307505 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Vertebral Bone Marrow Transplant from a Deceased Lung Transplant Donor: Durable Hematopoiesis and Immune Tolerance

Project description:Background: Primary immunodeficiency patients are ineligible for lung transplant (LTX) due to futility and bone marrow transplant (BMT) for lung failure. We hypothesized that using marrow extracted from the vertebral bodies (VB) of a deceased lung donor with partial HLA-match would be able to establish persistent hematopoiesis and generate immunity and tolerance. Methods: A teenager with severe combined immunodeficiency in lung failure due to recurrent pneumonias underwent LTX in 2016 from a 1/8 HLA allele-matched unrelated donor followed by reduced intensity conditioning and infusion of T cell/B cell-depleted cryopreserved VB marrow 4 months later. Results: Immune competence and donor-derived thymopoiesis were evident by six months post-BMT, while immunosuppression was withdrawn at 16-month post-BMT. Donor T cell (>95%) and myeloid chimerism (7-10%) have persisted for over nine years. At two years post-BMT, circulating donor-derived T cells were hyporesponsive to host dendritic cells in vitro. T-cell receptor clonotyping revealed the disappearance of host-reactive clones identifiable in the marrow graft, while circulating donor T cells exhibited downmodulation of signaling pathways for cytotoxicity/rejection, paired with upregulated immunomodulatory pathways, suggesting active suppression. In parallel, circulating predominantly host monocytes upregulated signaling pathways compared to their donor-derived counterparts, indicating active interactions between post-thymic donor T cells and host monocytes. Conclusion: In summary, durable hematopoietic engraftment and protective immunity were demonstrable for the first time in a patient receiving deceased donor vertebral bone marrow graft. Moreover, tolerance exceeding 8-years without immunosuppression was attainable.

2025-09-01 | GSE305710 | GEO

Durable Alterations of Hematopoiesis and Chromatin post-COVID-19

Project description:Durable Alterations of Hematopoiesis and Chromatin post-COVID-19

| PRJNA808241 | ENA

Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [MultiomeRNA]

Project description:Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [MultiomeRNA]

| PRJNA808248 | ENA

Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [snATAC-seq]

Project description:Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [snATAC-seq]

| PRJNA808247 | ENA

Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [MultiomeATAC-seq]

Project description:Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [MultiomeATAC-seq]

| PRJNA808249 | ENA

Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [bulkRNA-Seq]

Project description:Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [bulkRNA-Seq]

| PRJNA983776 | ENA

Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [Bulk ATAC-seq]

Project description:Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [Bulk ATAC-seq]

| PRJNA785568 | ENA

Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Project description:This pilot phase II trial studies how well giving donor T cells after donor stem cell transplant works in treating patients with hematologic malignancies. In a donor stem cell transplant, the donated stem cells may replace the patient’s immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor’s T cells (donor lymphocyte infusion) after the transplant may help increase this effect.

| 2143763 | ecrin-mdr-crc

Gene expression in donor kidney biopsies prior to kidney transplantation

Project description:Donor organ shortage, growing waiting lists and organ discard rates are key problems in kidney transplantation. Donor organ quality is a critical factor determining post-transplant graft outcomes. However, organ quality is difficult to predict. Balancing the use of marginal donors without affecting outcomes is a main issue in the transplant field. The decision of acceptance of a kidney organ for transplantation is mainly based on donor organ biopsy findings, even though there are recognized limitations. The lack of better measures of organ quality at the time of transplantation as a predictor of performance graft outcome is a serious clinical challenge. Herein, we propose the use of a limited set of genes that captures intrinsic biology of kidney donor organs to improve available scoring systems. We studied gene expression in 192 deceased donor kidney biopsies and evaluated short-term outcomes which included delayed graft function and eGFR (high versus low) at 24 months for 168 kidney transplant recipients.

2022-06-13 | GSE147451 | GEO

Gene expression-based, individualized outcome prediction for osteoporosis with vertebral fracture

Project description:This study aims to identify specific miRNAs profiles in osteoporotic patients with and without vertebral fractures. MiRNAs array analysis was performed on the plasma samples including a pool of 6 miRNA samples from osteoporotic patients with vertebral fractures, a pool of 6 miRNA samples from osteoporotic patients without fracture and another pool of 6 miRNA samples from nonosteoporotic patients to identify regulated miRNAs in the plasma.

2020-01-12 | GSE93883 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data