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Space Associated Stem Cell Hallmarks of Aging in Astronauts

ABSTRACT: Space Associated Stem Cell Hallmarks of Aging in Astronauts

PROVIDER: PRJNA1311158 | ENA |

REPOSITORIES: ENA

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Space Associated Stem Cell Hallmarks of Aging in Astronauts

Project description:Space Associated Stem Cell Hallmarks of Aging in Astronauts

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Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station

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Effects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station

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Nanobioreactor Detection of Space-Associated Hematopoietic Stem and Progenitor Cell Aging

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SCD – Stem Cell Differentiation on board the International Space Station [RNA-seq]

Project description:The bone loss observed in astronauts and animal models after spaceflight is attributable to alterations in the bone tissue formation that depends from the continuous remodeling through the activities of bone-resorbing osteoclasts of hematopoietic lineage and bone-forming osteoblasts of mesenchymal origin. This disease is frequent in aged people, but develops much more rapidly in space. Our experiment, selected by ESA (European Space Agency), aimed to determine how human bone marrow mesenchymal stem cells (hBMSCs) react and differentiate in real microgravity, on board the International Space Station, in approx. 2 weeks time.

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SCD – Stem Cell Differentiation on board the International Space Station [microarray on total RNA]

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SCD – Stem Cell Differentiation on board the International Space Station [miRNA-seq on miRNAs from exosomes]

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Altered translation elongation contributes to key hallmarks of aging in killifish brain

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