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Whole-genome gene expression profiles of non-tumorous human lung tissues

ABSTRACT: Whole-genome gene expression profiles of non-tumorous human lung tissues

PROVIDER: PRJNA131827 | ENA |

REPOSITORIES: ENA

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Whole-genome gene expression profiles of non-tumorous human lung tissues

Project description:This SuperSeries is composed of the following subset Series: GSE23352: Whole-genome gene expression profiles of non-tumorous human lung tissues: Laval set GSE23529: Whole-genome gene expression profiles of non-tumorous human lung tissues: UBC set GSE23545: Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set Refer to individual Series

2012-06-10 | E-GEOD-23546 | biostudies-arrayexpress

Whole-genome gene expression profiles of non-tumorous human lung tissues: Laval set

2012-06-11 | GSE23352 | GEO

Whole-genome gene expression profiles of non-tumorous human lung tissues: UBC set

2012-06-11 | GSE23529 | GEO

Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set

2012-06-11 | GSE23545 | GEO

Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set

2012-06-10 | E-GEOD-23545 | biostudies-arrayexpress

Whole-genome gene expression profiles of non-tumorous human lung tissues: Laval set

2012-06-10 | E-GEOD-23352 | biostudies-arrayexpress

Whole-genome gene expression profiles of non-tumorous human lung tissues: UBC set

Project description:We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD). The samples from the University of British Columbia (UBC) were derived from a long-standing tissue bank started by Drs. James C. Hogg and Peter D. Paré (Ding L, Quinlan KB, Elliott WM, Hamodat M, Paré PD, Hogg JC, Hayashi S. A Lung Tissue Bank for Gene Expression Studies in Chronic Obstructive Pulmonary Disease. COPD: Journal of Chronic Obstructive Pulmonary Disease 2004;1:191-204 (PMID 17136987)). Lung specimens were obtained from patients undergoing lung surgery. Primarily this was for resection of benign or malignant lesions. Some were the diseased lungs from transplant recipients. Patients are approached prior to surgery and asked if they would like to donate a portion of the lung tissue that is to be removed for research. It is explained that this would be done after the appropriate diagnostic specimens are taken and that only portions of lung that would be otherwise discarded will be used for research. A small number of lung samples were obtained at the time of autopsy. Immediately after resection, the lobes or lungs were inflated using a 50% mixture of Cryomatrix and saline. The specimens were then frozen in liquid nitrogen fumes and stored at -80C for later RNA extraction. RNAs were extracted and then hybridized to a single custom-made whole-genome human Affymetrix array.

2012-06-10 | E-GEOD-23529 | biostudies-arrayexpress

Transcription profiling of tumorous and non tumorous live from Parkin-/- mice suggestsa role for Parkin as a tumor suppressor gene for hepatocellular carcinoma

Project description:To provide an insight into the molecular mechanism by which parkin deficiency contributes to hepatocarcinogenesis, we analyzed gene expression profiles of nontumorous and tumorous liver tissues from parkinâ/â mice using cDNA microarray analyses. Experiment Overall Design: We analysed the up and down regulated genes in tumorous and non-tumorous liver tissues of parkin-/- mice compared with normal liver tissues of wild-type mice.

2008-06-16 | E-GEOD-9651 | biostudies-arrayexpress