Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1320984 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:The purpose of this study is the investigation of new host-microbiome interactions promoting adenoma formation and adenocarcinoma progression. For that purpose, the investigators will collect saliva, stool and colon biopsy specimens from patients referred to colonoscopy or surgical resection of colorectal tumor. Besides, a questionnaire about diet, lifestyle and medical history will be collected. Sample analysis will involve simultaneous characterization of host and microbiota genomic and transcriptomic components.
| 2228596 | ecrin-mdr-crc
Project description:Neutrophils are the most abundant leukocytes in human peripheral blood but exhibit considerable heterogeneity, with distinct subsets characterized by diverse functional states. Lipopolysaccharide (LPS) has been shown to drive neutrophil senescence, a process distinct from apoptosis. However, the global transcriptional landscape of LPS-induced aged neutrophils remains largely unexplored. Here, we performed whole-transcriptome RNA sequencing (RNA-seq) on primary human neutrophils isolated from healthy donors. Neutrophils were treated with LPS to induce senescence, with untreated cells serving as controls. Our comparative transcriptomic analysis revealed that senescent neutrophils display significant upregulation of multiple genes associated with neutrophil extracellular trap (NET) formation compared to non-aged neutrophils. This dataset provides a comprehensive resource for investigating the molecular signatures underlying neutrophil senescence and its potential implications in inflammation and host defense.
2026-04-02 | GSE326268 | GEO
Project description:Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high throughput sequencing study investigating genome-wide DNA methylation patterns in a large cohort of 51 tumor and 53 benign prostate samples using MeDIP-Seq. Comparative analyses identified more than 147,000 cancer-associated epigenetic alterations. Additionally, global methylation patterns demonstrate significant differences based on the TMPRSS2:ERG rearrangement status. We propose the hypermethylation of miRNA-26a as an alternative pathway of ERG rearrangement independent EZH2 activation. The observed increase in differential methylation events in fusion negative tumors can explain the tumorigenic process in the absence of genomic rearrangements. Genomewide examination of methylation profiles in 51 prostate cancer samples
2012-12-06 | E-GEOD-35342 | biostudies-arrayexpress
Project description:This dataset contains comparative mass spectrometry analysis investigating proline hydroxylation of synthetic HIV-2 Vpx peptides under two conditions: with and without PHD3 enzyme treatment. The analysis was performed using a high-resolution mass spectrometer coupled to a nano-LC system. The dataset provides comprehensive information about post-translational modifications, focusing on site-specific proline hydroxylation events.
| PXD059242 | JPOST Repository
Project description:Global comparative transcriptome analysis of cartilage formation in vivo
| PRJNA152441 | ENA
Project description:This SuperSeries is composed of the following subset Series: GSE12997: Comparative transcriptomic analysis of BA- or BL- associated murine colonic epithelium GSE12998: Comparative transcriptomic analysis of BA- or BL- associated murine colonic epithelium after O157 infection Refer to individual Series
2011-01-27 | E-GEOD-13061 | biostudies-arrayexpress
Project description:The aim of this work was to analyse the transcriptome of the mice cerebral cortex (or neocortex) during embryogenesis and at post-natal age. This complete transcriptomic analysis was dedicated to the analysis of the genes participating in the homeostasis of Zinc during brain development and formation. Our study represents a detailed analysis of transcriptomes during formation and dvelopment of the brain cortex, with biologic triplicates, generated by RNA-seq technology. This will provide a framework for comparative investigations of expression profiles. Our work offers an accurate quantitative and qualitative evaluation of mRNA content during mice embryogenesis.
2020-07-19 | GSE154677 | GEO