Project description:Oreochromis niloticus represents a critically important species in the aquaculture industry due to its economic significance. Probiotics used as feed additives are known to enhance the growth performance and health of tilapia. However, the underlying mechanisms by which these benefits are conferred remain poorly understood. Here, we demonstrate that Lactobacillus salivarius exhibits significant growth performance-enhancing effects when used as a feed additive. Utilizing multi-omics approaches, our results revealed that L. salivarius significantly modulates the composition and abundance of the intestinal microbiota. Bile acids, choline, and tryptophan were identified as pivotal factors in the microbial-mediated modulation of systemic metabolism. Additionally, we have delineated a single-cell atlas of the tilapia intestine for the first time, discovering that L. salivarius_01 increases the populations of intestinal epithelial cells, immune cells, and epithelial stem cells. A broad spectrum of developmentally relevant genes and pathways were found to be activated. This study significantly advances the application of probiotics in promoting sustainable aquaculture practices.
2025-12-18 | GSE284663 | GEO
Project description:the biofloc-based shrimp culture systems
| PRJNA817401 | ENA
Project description:Bacterial diversity of Ettlia sp. based recirculating aquaculture systems
| PRJNA406893 | ENA
Project description:bacterial diversity of Ettlia sp. based recirculating aquaculture systems
| PRJNA406887 | ENA
Project description:Microbial community of biofloc-based recirculating aquaculture system
| PRJNA639212 | ENA
Project description:Microbial diversity of shrimp biofloc technology systems
| PRJNA738270 | ENA
Project description:Use of Fish Oral Vaccine in Tilapia Aquaculture Systems
| PRJNA1122951 | ENA
Project description:Studies of microbial Penaeus monodon biofloc based aquaculture environment
